Purchase of Equipment for Polypeptide Synthesis, Purification, and Analysis

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。在化学研究仪器和设施：多用户计划（CRIF：MU）的支持下，路易斯安那州立大学化学系将获得圆二色光谱仪系统。光谱仪将被安置在路易斯安那州立大学蛋白质设施，并将被路易斯安那州立大学和区域机构的教师用来表征蛋白质结构。 将要进行的一些研究包括：（1）DNA聚合酶的蛋白质折叠;（2）抑制蛋白质-蛋白质相互作用的肽和蛋白质的研究;（3）含有后修饰氨基酸的复合肽的合成和表征;（4）糖蛋白的生物物理和结构研究;（5）用于生物学和生物材料的设计肽;（6）用于生物学和生物材料的设计肽;（7）用于生物学和生物材料的设计肽;（8）用于生物学和生物材料的设计肽;（9）用于生物学和生物材料的设计肽。乙酰辅酶A羧化酶抑制剂的晶体学分析。圆二色光谱仪，就像在这个奖项下购买的一个，允许化学家探测大生物分子的二级和高级结构。 深入了解这些复杂分子的结构有助于科学家了解这些分子在生命系统（包括人类）中的功能方式。 除了该设备所带来的更广泛的科学影响外，该光谱仪还将用于在路易斯安那州立大学培训一批非常多样化的年轻科学家。

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).With support from the Chemistry Research Instrumentation and Facilities: Multiuser program (CRIF:MU), the Department of Chemistry at Louisiana State University will acquire a Circular Dichroism spectrometer system. The spectrometer will be housed in the LSU protein facility and will be used by faculty at LSU and regional institutions to characterize protein structure. Some of the studies to be carried out include: (1) protein folding of DNA polymerases; (2) the study of peptides and proteins for inhibition of protein-protein interactions; (3) the synthesis and characterization of complex peptides containing post-translationally modified amino acids; (4) biophysical and structural investigations of glycoproteins; (5) designed peptides for biology and biomaterials; and (6) the crystallographic analysis of inhibitors bound to acetyl-CoA carboxylase. Circular Dichroism spectrometers, like the one purchased under this award, allow chemists to probe the secondary and higher structures in large biomolecules. Insight into the structure of these complex molecules helps scientists to understand the way that these molecules function in living systems, including humans. Besides the broader scientific impact of the science enabled by this equipment, the spectrometer will be used to train a very diverse group of young scientists at Louisiana State University.