CAREER: Understanding Molecular Networks Controlling Plant Glucosinolate Metabolism
职业:了解控制植物芥子油苷代谢的分子网络
基本信息
- 批准号:0845162
- 负责人:
- 金额:$ 67.6万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-08-01 至 2014-07-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).Intellectual Merit: Plants produce thousands of chemicals that are important to their growth, development and interaction with the environment. Many of these chemicals, such as glucosinolates, impact agricultural practice, human nutrition and health. Glucosinolates are a major group of thioglucosides with diverse biological activities, including defense against pathogens and insects. They are present in important Brassica crops as well as in the model plant Arabidopsis, which will be used for the proposed research. In order to engineer plants to improve crop quality and yield, create renewable energy and develop nutraceuticals, it will be essential to define the organization and connectivity of complex metabolic networks like those involved in glucosinolate production. The research team will use modern biological tools to understand the chemical networks that regulate plant glucosinolate metabolism. The project is expected to identify novel chemical components including proteins and metabolites and put them into functional context of glucosinolate metabolism. The research is expected to provide comprehensive knowledge of regulatory and metabolic mechanisms underlying glucosinolate metabolism that will help to develop crops with enhanced defense and improved quality. The approaches employed will provide technology development for future network analysis of other important plant pathways.Broader Impacts: In addition to the scientific impacts, this project will involve multidisciplinary training of students at different levels, as well as bring current knowledge of the plant chemical factory and modern functional genomics to high school classrooms. Education and training of high school teachers and students will facilitate effective preparation of our next-generation scientists and citizens with cutting-edge biological sciences. Educational/training activities will be developed for high school students and teachers in functional genomics, including online functional genomics resources. The large-scale data generated by this project will provide excellent materials for active learning, critical thinking, and problem solving. Thus, the broader impacts include advancing the discovery and understanding of essential plant chemical processes and establishing a platform to expose modern scientific research and technologies to high school teachers and their students.
该奖项是根据2009年美国复苏和再投资法案(公法111-5)资助的。智力优势:植物产生数千种化学物质,这些化学物质对它们的生长、发育以及与环境的相互作用都很重要。其中许多化学品,如硫代葡萄糖苷,影响农业实践、人类营养和健康。硫代葡萄糖苷是一类主要的硫代葡萄糖苷类,具有多种生物活性,包括防御病原体和昆虫。它们存在于重要的芸苔属作物以及模式植物拟南芥中,拟南芥将用于拟议的研究。为了改造植物以提高作物质量和产量,创造可再生能源和开发营养保健品,有必要确定复杂代谢网络的组织和连通性,如硫代葡萄糖苷生产中涉及的代谢网络。研究小组将使用现代生物学工具来了解调节植物硫代葡萄糖苷代谢的化学网络。该项目预计将识别新的化学成分,包括蛋白质和代谢物,并将它们置于硫代葡萄糖苷代谢的功能背景下。该研究有望提供硫代葡萄糖苷代谢的调控和代谢机制的全面知识,这将有助于开发具有增强防御能力和改善品质的作物。所采用的方法将为未来其他重要植物通路的网络分析提供技术发展。更广泛的影响:除了科学上的影响,该项目还将涉及对不同层次学生的多学科培训,并将植物化工厂和现代功能基因组学的最新知识带入高中课堂。高中教师和学生的教育和培训将有助于为我们的下一代科学家和公民提供尖端生物科学的有效准备。为高中学生和教师开展功能基因组学教育/培训活动,包括在线功能基因组学资源。该项目产生的大规模数据将为主动学习、批判性思维和解决问题提供优秀的材料。因此,更广泛的影响包括促进对植物基本化学过程的发现和理解,并建立一个向高中教师和学生展示现代科学研究和技术的平台。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Sixue Chen其他文献
Tissue-specific and Developmental Regulation of Camptothecin and 10-hydroxycamptothecin Levels in Camptotheca acuminate
喜树中喜树碱和 10-羟基喜树碱水平的组织特异性和发育调节
- DOI:
10.7016/bbas.200510.0325 - 发表时间:
2005 - 期刊:
- 影响因子:0
- 作者:
Xiufeng Yan;Yang Wang;Yuhong Zhang;Tao Yu;Mei;Shiying Ju;Sixue Chen - 通讯作者:
Sixue Chen
Comparison of the adverse events of anterior cervical disc replacement versus anterior cervical discectomy and fusion
前路颈椎间盘置换术与前路颈椎间盘切除融合术不良事件的比较
- DOI:
- 发表时间:
2018 - 期刊:
- 影响因子:1.6
- 作者:
He Zhao;Lijun Duan;Yu;Yongdong Yang;Xiangsheng Tang;Ding;Yang Xiong;Zhen;Chuanhong Li;Sixue Chen;Tao Liu;Xing Yu - 通讯作者:
Xing Yu
An Improved Isotope-coded Affinity Tag Technology for Thiol Redox Proteomics
用于硫醇氧化还原蛋白质组学的改进同位素编码亲和标签技术
- DOI:
- 发表时间:
2012 - 期刊:
- 影响因子:0
- 作者:
Ning Zhu;Mengmeng Zhu;Shaojun Dai;R. Zheng;Sixue Chen - 通讯作者:
Sixue Chen
Analysis of Sugar Beet SUMO System Members and their Responses to Abiotic Stresses
- DOI:
10.1007/s12355-025-01606-1 - 发表时间:
2025-05-16 - 期刊:
- 影响因子:2.000
- 作者:
Jiajia Zhang;Jiaxin Fu;Chunquan Ma;Bing Yu;Sixue Chen;Haiying Li - 通讯作者:
Haiying Li
Proteomics in the Classroom: An Investigative Study of Proteins in Microorganisms
课堂上的蛋白质组学:微生物中蛋白质的调查研究
- DOI:
10.1525/abt.2012.74.4.6 - 发表时间:
2012 - 期刊:
- 影响因子:0
- 作者:
Jonathan P. Benskin;Sixue Chen - 通讯作者:
Sixue Chen
Sixue Chen的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Sixue Chen', 18)}}的其他基金
Metabolomics of stomatal immunity in the disease triangle
疾病三角区气孔免疫的代谢组学
- 批准号:
2340995 - 财政年份:2022
- 资助金额:
$ 67.6万 - 项目类别:
Standard Grant
Metabolomics of stomatal immunity in the disease triangle
疾病三角区气孔免疫的代谢组学
- 批准号:
1920420 - 财政年份:2020
- 资助金额:
$ 67.6万 - 项目类别:
Standard Grant
Deciphering the guard cell metabolome in plant pathogen defense
解读植物病原体防御中的保卫细胞代谢组
- 批准号:
1758820 - 财政年份:2018
- 资助金额:
$ 67.6万 - 项目类别:
Standard Grant
Collaborative Research: Redox Regulation of Protein Kinase Functions in Guard Cell Signaling
合作研究:保卫细胞信号传导中蛋白激酶功能的氧化还原调节
- 批准号:
1412547 - 财政年份:2014
- 资助金额:
$ 67.6万 - 项目类别:
Standard Grant
COLLABORATIVE RESEARCH: Metabolomic Characterization of Red Light and CO2 Signaling in Guard Cells and Mesophyll Cells
合作研究:保卫细胞和叶肉细胞中红光和 CO2 信号传导的代谢组学特征
- 批准号:
1158000 - 财政年份:2012
- 资助金额:
$ 67.6万 - 项目类别:
Continuing Grant
Collaborative Research: Redox and Metabolomic Regulatory Mechanisms Underlying Guard Cell ABA Signal Transduction
合作研究:保卫细胞 ABA 信号转导背后的氧化还原和代谢调节机制
- 批准号:
0818051 - 财政年份:2008
- 资助金额:
$ 67.6万 - 项目类别:
Continuing Grant
相似国自然基金
Navigating Sustainability: Understanding Environm ent,Social and Governanc e Challenges and Solution s for Chinese Enterprises
in Pakistan's CPEC Framew
ork
- 批准号:
- 批准年份:2024
- 资助金额:万元
- 项目类别:外国学者研究基金项目
Understanding structural evolution of galaxies with machine learning
- 批准号:n/a
- 批准年份:2022
- 资助金额:10.0 万元
- 项目类别:省市级项目
Understanding complicated gravitational physics by simple two-shell systems
- 批准号:12005059
- 批准年份:2020
- 资助金额:24.0 万元
- 项目类别:青年科学基金项目
相似海外基金
CAREER: Understanding the Molecular Mechanisms of Insect Cuticular Chitin Maintenance
职业:了解昆虫表皮几丁质维持的分子机制
- 批准号:
2338209 - 财政年份:2024
- 资助金额:
$ 67.6万 - 项目类别:
Continuing Grant
CAREER: Understanding Dielectrophoretic Molecular Transport
职业:了解介电泳分子传输
- 批准号:
2337878 - 财政年份:2024
- 资助金额:
$ 67.6万 - 项目类别:
Continuing Grant
CAREER: Molecular-level Understanding of Conductive Polymer Properties
职业:对导电聚合物特性的分子水平理解
- 批准号:
2235161 - 财政年份:2023
- 资助金额:
$ 67.6万 - 项目类别:
Continuing Grant
CAREER: Molecular Approaches for Understanding Defect-Porosity Relationships in Microporous Organic Polymers
职业:理解微孔有机聚合物中的缺陷-孔隙率关系的分子方法
- 批准号:
2237499 - 财政年份:2023
- 资助金额:
$ 67.6万 - 项目类别:
Standard Grant
CAREER: Understanding Molecular Mechanisms Underlying Chemical Behavior of Pollutants in Heterogeneous Environmental Systems
职业:了解异质环境系统中污染物化学行为的分子机制
- 批准号:
2144591 - 财政年份:2022
- 资助金额:
$ 67.6万 - 项目类别:
Continuing Grant
CAREER: Understanding the Interactions Between Surfactants and Metallic Nanoparticles Using Molecular Simulation
职业:利用分子模拟了解表面活性剂和金属纳米颗粒之间的相互作用
- 批准号:
2046095 - 财政年份:2021
- 资助金额:
$ 67.6万 - 项目类别:
Continuing Grant
CAREER: Understanding Molecular Interactions and Processability for the Design and Manufacture of Ultrafine Electrospun Polymer Fibers
职业:了解超细静电纺聚合物纤维设计和制造的分子相互作用和加工性能
- 批准号:
2045465 - 财政年份:2021
- 资助金额:
$ 67.6万 - 项目类别:
Standard Grant
CAREER: Machine Learning Approaches to Understanding Molecular Mechanisms Underlying Convergent Evolution of Vocal Learning Behavior
职业:机器学习方法来理解声音学习行为趋同进化的分子机制
- 批准号:
2046550 - 财政年份:2021
- 资助金额:
$ 67.6万 - 项目类别:
Continuing Grant
CAREER: Understanding the Molecular and Structural Composition of Aggressive Cancers using Deep Ultraviolet Spectroscopy and Imaging
职业:利用深紫外光谱和成像了解侵袭性癌症的分子和结构组成
- 批准号:
1752011 - 财政年份:2018
- 资助金额:
$ 67.6万 - 项目类别:
Standard Grant
CAREER: Molecular Understanding and Catalyst Design for the Direct Synthesis of H2O2
职业:直接合成 H2O2 的分子理解和催化剂设计
- 批准号:
1553137 - 财政年份:2016
- 资助金额:
$ 67.6万 - 项目类别:
Standard Grant