CAREER: Technologies for Genome-wide In vivo Study of Neuronal (Axonal) Degeneration
职业:神经元(轴突)变性的全基因组体内研究技术
基本信息
- 批准号:0845347
- 负责人:
- 金额:$ 40万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-01-01 至 2014-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
0845347M. YanikAxonal degeneration is a major process occurring during early stages of neurodegenerative diseases. Understanding molecular mechanisms of axonal degeneration may lead to therapeutic strategies for many devastating diseases. In vivo study of axonal degeneration following physical injury has been largely limited to organisms with complex nervous systems, where difficulty of performing injury and genetic studies is significantly limiting discovery of molecular pathways. Small-animal models like C. elegans allow powerful genetic manipulations. In this project, cellular pathways of axonal degeneration in C. elegans will be studied using genetic, microfluidic and optical technologies. Several mutant strains will be characterized for understanding effects of various molecular pathways on axonal degeneration. In vivo genome-wide studies of axonal degeneration will be conducted following physical injury at sub-cellular resolution. The proposed studies can allow rapid discovery of genetic targets and cellular pathways involved in early stages of neurodegeneration with potential impact on both fundamental science, as well as, medicine. In synergy with the research component, this proposal will enable a substantial educational and outreach program. Education and research will be integrated by (1) providing the students (undergraduate, masters, and graduate) with exciting and valuable research opportunities at MIT in a new and significant research field, (2) working with secondary school outreach programs to help young students start a career in science and technology, (3) trying to attract underrepresented minority students (particularly African Americans, American Indians, Hispanic Americans as well as others who add diversity to MIT's School of Engineering) to work in our research group, (4) feeding new research results back into the courses that the PI is currently developing, and (5) reaching community at large.
0845347米。轴突变性是发生在神经退行性疾病早期的一个重要过程。了解轴突变性的分子机制可能会导致许多毁灭性疾病的治疗策略。物理损伤后轴突变性的体内研究主要局限于具有复杂神经系统的生物体,在这些生物体中,进行损伤和遗传研究的困难极大地限制了分子途径的发现。像秀丽隐杆线虫这样的小动物模型允许进行强大的基因操作。本项目将利用遗传、微流体和光学技术研究秀丽隐杆线虫轴突退化的细胞途径。一些突变株将被描述为了解不同分子途径对轴突变性的影响。在亚细胞分辨率下进行物理损伤后轴突变性的体内全基因组研究。拟议的研究可以快速发现神经退行性疾病早期阶段的遗传靶点和细胞通路,对基础科学和医学都有潜在的影响。在与研究组成部分的协同作用下,该提案将使一个实质性的教育和推广计划成为可能。教育和研究将通过以下方式整合:(1)为学生(本科生、硕士和研究生)在麻省理工学院一个新的重要研究领域提供令人兴奋和有价值的研究机会;(2)与中学外展项目合作,帮助年轻学生开始在科学和技术领域的职业生涯;(3)努力吸引代表性不足的少数民族学生(特别是非洲裔美国人、美洲印第安人、(4)将新的研究成果反馈到PI目前正在开发的课程中,(5)影响到整个社区。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Mehmet Yanik其他文献
The Congruence of Teaching Styles Used by Turkish Physical Education Teachers with National Curriculum’ Goals and Learning Outcomes
土耳其体育教师使用的教学风格与国家课程目标和学习成果的一致性
- DOI:
10.47778/ejsse.1323148 - 发表时间:
2023 - 期刊:
- 影响因子:0
- 作者:
Mehmet Yanik;Tarık Balci;Zekeriya Goktas - 通讯作者:
Zekeriya Goktas
Effect of Participation in School Sports Teams on Middle School Students’ Engagement in School
参加学校运动队对中学生学业投入的影响
- DOI:
- 发表时间:
2018 - 期刊:
- 影响因子:3
- 作者:
Mehmet Yanik - 通讯作者:
Mehmet Yanik
Mehmet Yanik的其他文献
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