CAREER: Engineered biomaterial gradients for control of neural cells

该奖项由2009年美国复苏和再投资法案(公法111-5)资助。0846328简短智能优点：拟议的微流体系统独特地允许在生理相关的3D环境中检查各种因素的组合，对于阐明支撑神经发展的指导原则以及识别和实施再生疗法具有很大的前景，特别是与生长锥和丝状突起(细胞中细小的细胞质突起)动态的定量建模相结合。广泛影响：数千名患者患有中枢神经系统(CNS)创伤和退行性疾病，并最终可能从这项研究中受益。罗格斯大学的未来学者计划每年招收200名经济困难的学生--或者说在这项计划的过程中招收1000名学生，而罗格斯大学的家庭社区在人口结构上基本上是由代表不足的群体主导的。拟议的计划为这些学生提供了独特的机会，这些机会将使他们对生物医学和组织工程方面的教育和培训感到兴奋，并有助于塑造我们科学和工程界未来的领导者。

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).0846328ShreiberIntellectual Merit: The proposed microfluidics system uniquely allows examination of a combinations of factors in a physiologically relevant 3D environment, and holds great promise for elucidating guidance principles that underlay neurodevelopment and for identifying and implementing regenerative therapies, particularly in conjunction with the quantitative modeling of growth cone and filopodial (thin cytoplasmic protusions from the cell) dynamics.Broader Impact: Thousands of patients suffer from central nervous system (CNS) trauma and degenerative disorders and may ultimately benefit from this research. Two hundred economically disadvantaged students are recruited into the Future Scholars program each year - or 1,000 students over the course of this proposal, and Rutgers' home communities are largely dominated demographically by under-represented groups. The proposed initiatives provide unique opportunities to these students that will excite them about education and training in biomedical and tissue engineering and helps shape future leaders of our scientific and engineering communities.