REU Site: Cellular Bioengineering -- From Biomaterials to Stem Cells

REU 网站：细胞生物工程——从生物材料到干细胞

• 批准号: 1559968
• 负责人: David Shreiber
• 金额: $ 41.25万
• 依托单位: Rutgers University New Brunswick
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-10-01 至 2021-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1559968&HistoricalAwards=false
• 关键词: REU; Site; Cellular; Bioengineering; Biomaterials

The REU Site: Cellular Bioengineering -- From Biomaterials to Stem Cells offers students exciting research projects that introduce them to a broad array of topics grounded in Cellular Bioengineering. Cellular Bioengineering encompasses a number of cutting edge research fields and articulates with nanotechnology, advanced materials, systems biology and stem cells. Training undergraduate students with diverse backgrounds in Cellular Bioengineering will broaden the research base and lead to an expanded and better-trained workforce in this rapidly expanding field. Program elements in innovation, entrepreneurship, and translational research enhance the students' marketable skill set and increase the potential for their current and future discoveries to be converted to technological advances of great impact. Unlike the traditional research that undergraduates typically conduct, the REU Site program is leveraging broad-based training through engineering projects that additionally integrate efforts across the life sciences and physical sciences. The recruitment efforts specifically target individuals who normally have limited research opportunities, including those from underrepresented groups and from colleges without substantial graduate research and training. The program expects to expand the pipeline of students entering graduate programs, by helping to engage a group who would likely have not considered graduate school. The REU Site is employing standardized elements of research training and professional development to accelerate the students' learning curve and inoculate them into active laboratories that are pursuing high-impact Cellular Bioengineering research. The program is employing active mentoring, collaboration, and regular monitoring of the students to achieve its goals. Project areas that the students will work on include: 1) Multi-modal cues for phenotypic control of neural cells, 2) Polymer nanoformulations for delivery of macromolecular therapeutics, 3) High Throughput, Automated, Single Cell Electroporation, 4) Encapsulated MSC Regulation of Inflammatory Environments, 5) Cell and tissue engineering approaches to tendon and ligament healing, 6) Reprogrammed Stem Cells and 3-D Microenvironments, 7) High Throughput Platform for Drug Metabolism Screening in Fatty Liver Cells, 8) Interactions of lipid-based nanocarriers with vascular endothelia and macrophages, 9) Designing Scaffold Cues for Retinal Pigment Epithelial Tissue Engineering, 10) Subcellular structural dynamics and mechanotransduction to branching neurons, and 11) Non-destructive measurement of tissue morphomechanical properties. A Cellular Bioengineering Boot Camp introduces participants to laboratory and imaging skills that accelerates their integration into their research labs. A focus on Innovation and Entrepreneurship parallels the recent NSF I-Corps initiative for translational research to capitalize on the potential for new technology that emanates from the research. A component of the program is a clinical immersion, where the REU scholars will observe clinicians in the surgical unit. The Scholars use these experiences to identify needs and problems and brainstorm about innovations and technologies to solve these problems. Under the guidance of faculty from the Center for Innovative Ventures of Emerging Technologies, the students build business plans around these ideas. Weekly seminars and discussion groups allow tracking and monitoring of the Scholars' experiences while concurrently engaging them in professional development. Incorporation of a mentoring workshop for the graduate students who serve as "near-peer" mentors further broadens the impact of the program.

REU网站：细胞生物工程-从生物材料到干细胞为学生提供了令人兴奋的研究项目，向他们介绍了细胞生物工程的广泛主题。细胞生物工程包括许多前沿研究领域，并与纳米技术，先进材料，系统生物学和干细胞相结合。培养具有不同背景的细胞生物工程本科生将扩大研究基础，并导致在这个迅速扩大的领域扩大和训练有素的劳动力。创新，创业和转化研究的计划元素提高了学生的市场技能，并增加了他们当前和未来的发现转化为具有重大影响的技术进步的潜力。与本科生通常进行的传统研究不同，REU Site计划通过工程项目利用基础广泛的培训，这些项目还整合了生命科学和物理科学的工作。招聘工作专门针对那些通常研究机会有限的个人，包括来自代表性不足的群体和来自没有大量研究生研究和培训的大学的人。该计划预计将扩大学生进入研究生课程的管道，通过帮助从事一组谁可能没有考虑研究生院。REU网站采用研究培训和专业发展的标准化元素，以加速学生的学习曲线，并将他们纳入正在追求高影响力的细胞生物工程研究的活跃实验室。该计划采用积极的指导，合作，并定期监测学生，以实现其目标。学生将从事的项目领域包括：1）用于神经细胞表型控制的多模式线索，2）用于递送大分子治疗剂的聚合物纳米制剂，3）高通量、自动化、单细胞电穿孔，4）封装MSC对炎症环境的调节，5）肌腱和韧带愈合的细胞和组织工程方法，6）重编程干细胞和3-D微环境，7）脂肪肝细胞中药物代谢筛选的高通量平台，8）基于脂质的纳米载体与血管内皮细胞和巨噬细胞的相互作用，9）设计视网膜色素上皮组织工程的支架线索，10）亚细胞结构动力学和到分支神经元的机械转导，和11）组织形态力学性质的非破坏性测量。细胞生物工程靴子营介绍参与者的实验室和成像技能，加速他们融入他们的研究实验室。对创新和创业精神的关注与最近的NSF I-Corps转化研究计划相平行，以利用研究产生的新技术潜力。该计划的一个组成部分是临床沉浸，在那里REU学者将观察外科单位的临床医生。学者们利用这些经验来确定需求和问题，并就解决这些问题的创新和技术进行头脑风暴。在新兴技术创新创业中心教师的指导下，学生们围绕这些想法制定商业计划。每周的研讨会和讨论小组允许跟踪和监测学者的经验，同时让他们参与专业发展。为担任“近同行”导师的研究生开设辅导讲习班，进一步扩大了该方案的影响。