RUI: Nanoparticle Film Assemblies: Interfaces for Controlling the Nanoscale Adsorption Environment and Electrochemical Behavior of Immobilized Redox Proteins

RUI：纳米颗粒薄膜组件：用于控制固定化氧化还原蛋白的纳米级吸附环境和电化学行为的界面

• 批准号: 0847145
• 负责人: Michael Leopold
• 金额: $ 25.5万
• 依托单位: University of Richmond
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-02-15 至 2013-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0847145&HistoricalAwards=false
• 关键词: RUI; Nanoparticle; Film; Assemblies; Interfaces

Professor Michael C. Leopold of the University of Richmond is supported by the Analytical and Surface Chemistry Program in the Division of Chemistry to conduct research leading to the development of chemically modified gold nanoparticles assembled onto conducting surfaces, known as monolayer-protected clusters (MPCs), and to use this platform as a functional electrode component for protein monolayer electrochemistry to probe the electron transfer properties of immobilized redox proteins, while preserving their biological function. Experiments will be conducted to study the role of the core size and functionality of the MPCs, and the dependence of electron transfer rates on distance through the MPCs. Understanding of the interactions and charge transfer properties of proteins with these substrates will lead to a better realization of the potential of MPCs in many applications in bioanalytical chemistry leading to the development of miniaturized biosensors. This research will involve undergraduate students in an undergraduate institution in modern research methods and train them in state-of-the-art instrumentation.

Michael C.里士满大学的Leopold得到化学系分析和表面化学项目的支持，进行研究，开发组装在导电表面上的化学改性金纳米颗粒，称为单层保护簇（MPC），并使用该平台作为蛋白质单层电化学的功能电极组件，以探测固定化氧化还原蛋白的电子转移特性，同时保留其生物学功能。 实验将进行研究的核心大小和功能的MPC的作用，以及通过MPC的距离上的电子转移速率的依赖性。 了解蛋白质与这些底物的相互作用和电荷转移特性将导致更好地实现MPC在生物分析化学中的许多应用中的潜力，从而导致小型化生物传感器的发展。 这项研究将涉及在现代研究方法的本科院校的本科生，并在国家的最先进的仪器培训他们。