CAREER: Gated Conical Nanopores

印第安纳大学的Lane a . Baker教授得到了化学系分析和表面化学职业项目的支持，研究了合成锥形纳米孔膜的门控机制，并开发了一种基于纳米孔阻断的传感范例，这种纳米孔具有专门设计的表面化学物质。其原理是，与纳米颗粒结合的分析物将与磁性颗粒耦合，磁场将用于将整个颗粒组合从纳米孔中移除，导致电解质流动和电流变化，从而为分析物检测提供基础。在动态环境中准确、快速、灵敏地检测和定量小的、通常是短暂的化学和生化物种浓度是分析化学的一个挑战。开发新的低浓度分析物检测策略是对分析化学、电化学、纳米技术和生物技术等领域的重要贡献。研究生和本科生将接受最先进的分析技术培训，并将实施一项外展计划，其中包括视觉学习概念和利用视频会议与播客技术相协调的信息传播。

Professor Lane A. Baker of Indiana University is supported by the Analytical and Surface Chemistry CAREER Program in the Division of Chemistry to study the mechanisms for gating synthetic conical nanopore membranes, and to develop a sensing paradigm based on pore blocking by nanoparticles with specifically designed surface chemistries. The idea is that analytes bound to the nanoparticles will be coupled with magnetic particles and magnetic fields will be used to dislodge the entire particle assembly from the nanopores, resulting in flow of electrolytes and change in the current, thereby providing the basis for analyte detection. Accurate, rapid and sensitive detection and quantization of small, often transient, concentrations of chemical and biochemical species in a dynamic environment is a challenge in analytical chemistry. Developing new strategies for detection of analytes at low concentrations is an important contribution to the fields of analytical chemistry, electrochemistry, nanotechnology and biotechnology. Graduate and undergraduate students will be trained in state-of-the-art analytical techniques, and an outreach program will be implemented involving visual learning concepts and information dissemination using video conferencing in coordination with podcasting technology.