CAREER: Gated Conical Nanopores

印第安纳大学的Lane A.Baker教授得到化学系分析和表面化学职业计划的支持，研究合成锥形纳米孔膜的门控机制，并通过特殊设计的表面化学开发基于纳米颗粒阻孔的传感范例。其想法是，结合到纳米颗粒上的分析物将与磁性颗粒耦合，磁场将用于将整个颗粒组装从纳米孔中移出，导致电解液流动和电流变化，从而为分析物检测提供基础。在动态环境中准确、快速和灵敏地检测和量化微小的、通常是瞬时的化学和生化物种的浓度是分析化学中的一个挑战。开发检测低浓度分析物的新策略是对分析化学、电化学、纳米技术和生物技术领域的重要贡献。将对研究生和本科生进行最先进的分析技术培训，并将实施一项外联方案，涉及视觉学习概念和利用视频会议配合播客技术传播信息。

Professor Lane A. Baker of Indiana University is supported by the Analytical and Surface Chemistry CAREER Program in the Division of Chemistry to study the mechanisms for gating synthetic conical nanopore membranes, and to develop a sensing paradigm based on pore blocking by nanoparticles with specifically designed surface chemistries. The idea is that analytes bound to the nanoparticles will be coupled with magnetic particles and magnetic fields will be used to dislodge the entire particle assembly from the nanopores, resulting in flow of electrolytes and change in the current, thereby providing the basis for analyte detection. Accurate, rapid and sensitive detection and quantization of small, often transient, concentrations of chemical and biochemical species in a dynamic environment is a challenge in analytical chemistry. Developing new strategies for detection of analytes at low concentrations is an important contribution to the fields of analytical chemistry, electrochemistry, nanotechnology and biotechnology. Graduate and undergraduate students will be trained in state-of-the-art analytical techniques, and an outreach program will be implemented involving visual learning concepts and information dissemination using video conferencing in coordination with podcasting technology.