CAREER: REACTIONS OF ELECTROPHILIC METAL CENTERS WITH AROMATIC HETEROCYCLES

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。无机、生物无机和有机金属化学项目的CAREER研究奖支持加州大学洛杉矶分校Paula Diaconescu教授对惰性分子的激活和功能化进行基础研究。目标科学领域为：(1)开环和(2)芳香杂环的功能化。杂环中C-N键的活化在加氢脱氮过程中具有重要意义。杂环的官能化与有机合成有关。为了实现这些目标，设计了由螯合二茂铁基配体支持的亲电金属中心，以便在温和条件下进行转化。在教育方面，目前的项目是围绕以研究为工具，向各级学生讲授环境所面临的一些能源问题，并向他们展示化学如何在理解和解决这些问题方面发挥作用。为了达到一个广泛的高中学生群体，一个有效的策略，以更新教师对解决能源问题的研究进行了考虑。为此，提出了一系列关于如何在高中课堂上教授环境问题的讲习班。通过这种方式，它使未来的科学家能够研究对社会重要的问题。了解过渡金属存在下的C-N键断裂过程对于建立非均相机制和评估氢脱氮的温和条件是否可行具有重要意义，这将有助于缓解社会面临的一些能源问题。

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). This CAREER Research award in the Inorganic, Bioinorganic and Organometallic Chemistry program supports work by Professor Paula Diaconescu at the University of California, Los Angeles, to carry out fundamental/basic studies on the activation and functionalization of inert molecules. The scientific areas targeted are: (1) ring-opening and (2) functionalization of aromatic heterocycles. The activation of C-N bonds in heterocycles is important in the context of hydrodenitrogenation processes. The functionalization of heterocycles is relevant to organic synthesis. To achieve these goals, electrophilic metal centers supported by chelating ferrocene-based ligands are designed in order to develop transformations under mild conditions. Educationally, the present project is structured around using research as a tool to teach students at all levels about some of the energy problems that are confronting the environment and showing them how chemistry can be useful in understanding and solving those problems. In an attempt to reach a wide group of high school students, an effective strategy to update teachers on research conducted towards solving energy problems is considered. To this end a series of workshops on how to teach environmental issues in the high school classrooms is proposed. In this way it prepares future scientists to work on problems important to society.Understanding the C-N bond breaking processes in the presence of transition metals is significant in establishing heterogeneous mechanisms and assessing whether mild conditions are viable for hydrodenitrogenation, one of the processes that will contribute to alleviating some of the energy problems faced by society.