CAREER: REACTIONS OF ELECTROPHILIC METAL CENTERS WITH AROMATIC HETEROCYCLES

该奖项是根据2009年《美国复苏和再投资法案》(公法111-5)提供资金的。无机化学、生物无机化学和金属有机化学项目的这一职业研究奖支持加州大学洛杉矶分校的Paula Diaconescu教授开展关于惰性分子的活化和功能化的基础/基础研究。目标科学领域是：(1)芳香杂环的开环和(2)芳香杂环的官能化。在加氢脱氮过程中，杂环中C-N键的活化是重要的。杂环的官能化与有机合成有关。为了实现这些目标，设计了以二茂铁络合基配体为载体的亲电金属中心，以便在温和的条件下进行转化。在教育方面，本项目的结构是将研究作为一种工具，向各级学生传授环境面临的一些能源问题，并向他们展示化学如何有助于理解和解决这些问题。为了接触到广泛的高中生群体，考虑了一种有效的策略，以更新教师对解决能源问题所进行的研究。为此，提议举办一系列关于如何在高中课堂上教授环境问题的讲习班。通过这种方式，它为未来的科学家研究对社会重要的问题做好了准备。了解过渡金属存在下的C-N键断裂过程对于建立多相机制和评估温和的加氢脱氮条件是否可行具有重要意义，加氢脱氮是有助于缓解社会面临的一些能源问题的过程之一。

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). This CAREER Research award in the Inorganic, Bioinorganic and Organometallic Chemistry program supports work by Professor Paula Diaconescu at the University of California, Los Angeles, to carry out fundamental/basic studies on the activation and functionalization of inert molecules. The scientific areas targeted are: (1) ring-opening and (2) functionalization of aromatic heterocycles. The activation of C-N bonds in heterocycles is important in the context of hydrodenitrogenation processes. The functionalization of heterocycles is relevant to organic synthesis. To achieve these goals, electrophilic metal centers supported by chelating ferrocene-based ligands are designed in order to develop transformations under mild conditions. Educationally, the present project is structured around using research as a tool to teach students at all levels about some of the energy problems that are confronting the environment and showing them how chemistry can be useful in understanding and solving those problems. In an attempt to reach a wide group of high school students, an effective strategy to update teachers on research conducted towards solving energy problems is considered. To this end a series of workshops on how to teach environmental issues in the high school classrooms is proposed. In this way it prepares future scientists to work on problems important to society.Understanding the C-N bond breaking processes in the presence of transition metals is significant in establishing heterogeneous mechanisms and assessing whether mild conditions are viable for hydrodenitrogenation, one of the processes that will contribute to alleviating some of the energy problems faced by society.