CAREER: REACTIONS OF ELECTROPHILIC METAL CENTERS WITH AROMATIC HETEROCYCLES

事业：亲电金属中心与芳香杂环的反应

• 批准号: 0847735
• 负责人: Paula Diaconescu
• 金额: $ 59万
• 依托单位: University of California-Los Angeles
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2014-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0847735&HistoricalAwards=false
• 关键词: CAREER; REACTIONS; ELECTROPHILIC; METAL; CENTERS

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). This CAREER Research award in the Inorganic, Bioinorganic and Organometallic Chemistry program supports work by Professor Paula Diaconescu at the University of California, Los Angeles, to carry out fundamental/basic studies on the activation and functionalization of inert molecules. The scientific areas targeted are: (1) ring-opening and (2) functionalization of aromatic heterocycles. The activation of C-N bonds in heterocycles is important in the context of hydrodenitrogenation processes. The functionalization of heterocycles is relevant to organic synthesis. To achieve these goals, electrophilic metal centers supported by chelating ferrocene-based ligands are designed in order to develop transformations under mild conditions. Educationally, the present project is structured around using research as a tool to teach students at all levels about some of the energy problems that are confronting the environment and showing them how chemistry can be useful in understanding and solving those problems. In an attempt to reach a wide group of high school students, an effective strategy to update teachers on research conducted towards solving energy problems is considered. To this end a series of workshops on how to teach environmental issues in the high school classrooms is proposed. In this way it prepares future scientists to work on problems important to society.Understanding the C-N bond breaking processes in the presence of transition metals is significant in establishing heterogeneous mechanisms and assessing whether mild conditions are viable for hydrodenitrogenation, one of the processes that will contribute to alleviating some of the energy problems faced by society.

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。无机，生物无机和有机化学计划的职业研究奖支持加州大学洛杉矶的Paula Diaconescu教授的工作，以进行惰性分子活化和功能化的基础/基础研究。 目标科学领域是：（1）开环和（2）芳香杂环的官能化。 杂环中C-N键的活化在加氢脱氮过程中是重要的。杂环的功能化与有机合成有关。 为了实现这些目标，亲电金属中心支持螯合二茂铁基配体的设计，以发展在温和条件下的转换。 在教育方面，本项目的结构是围绕使用研究作为一种工具，教导各级学生关于环境面临的一些能源问题，并向他们展示化学如何有助于理解和解决这些问题。 在试图达到一个广泛的高中生群体，一个有效的策略，以更新教师对解决能源问题进行的研究。 为此，建议举办一系列关于如何在高中课堂上教授环境问题的讲习班。 了解过渡金属存在下的C-N键断裂过程对于建立异质机制和评估温和条件下加氢脱氮是否可行具有重要意义，加氢脱氮是有助于缓解社会面临的一些能源问题的过程之一。