RUI: Electrophilic Reactions of Fluorosubstituted Alkenes- Predicting Regiochemical Product Distributions
RUI:氟代烯烃的亲电反应 - 预测区域化学产物分布
基本信息
- 批准号:0640547
- 负责人:
- 金额:$ 12.5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2007
- 资助国家:美国
- 起止时间:2007-03-01 至 2010-02-28
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This award to Professor Dale F. Shellhamer of the Chemistry Department at Point Loma Nazarene College in San Diego, CA has as its goal the understanding of the influence that vinyl fluorine atoms have on the product regiochemistry from electrophilic reactions with halogens, interhalogens, and open-ion electrophiles like triflic acid and chlorosulfonyl isocyanate. This is important since it is known that fluorine, more than any other element, has the ability to completely alter product regiochemistry for electrophilic reactions. In addition to the experimental studies, quantum chemical computational studies will be employed to predict and verify the anticipated drastic changes that fluorine atoms have on product distributions. Further, the proposed study with chlorosulfonyl isocyanate will provide a new class of fluoro beta-lactams, an important study since beta-lactam functionality is present in several classes of antibiotics. Further, studies of fluorine containing compounds are important since a large number of agrochemicals and pharmaceuticals contain fluorine atoms.Among the most important broader impacts of this research is the mentoring of undergraduate researchers and training them as future scientists in a predominantly undergraduate institution. Prof. Shellhamer and Point Loma Nazarene College are exemplary in this regard and they have an excellent record of their undergraduate research participants obtaining advanced degrees in science and medicine. They also have an excellent record of participation by minority and women students and it is expected that this will continue. Further, as mentioned above, because fluorine is found in many pharmaceuticals and agrochemicals, understanding the chemistry of fluorine will help in the design of new generations of these substances.
该奖项授予加州圣地亚哥洛马拿撒勒学院化学系的Dale F. Shellhamer教授,其目标是了解乙烯基氟原子对与卤素、卤素间素和开放离子亲电试剂(如三羧酸和氯磺酰异氰酸酯)发生的亲电反应的产物区域化学的影响。这一点很重要,因为我们知道氟比其他任何元素都更有能力完全改变亲电反应的产物区域化学。除实验研究外,量子化学计算研究将用于预测和验证氟原子对产品分布的预期剧烈变化。此外,拟议的氯磺酰异氰酸酯研究将提供一类新的氟β -内酰胺,这是一项重要的研究,因为β -内酰胺的功能存在于几类抗生素中。此外,对含氟化合物的研究很重要,因为大量农用化学品和药品都含有氟原子。这项研究最重要的广泛影响之一是指导本科生研究人员,并在一个以本科生为主的机构中将他们培养成未来的科学家。Shellhamer教授和Point Loma Nazarene学院在这方面堪称典范,他们的本科生研究参与者获得科学和医学高级学位的记录非常出色。它们在少数民族和女性学生的参与方面也有良好的记录,预计这种情况将继续下去。此外,如上所述,由于许多药品和农用化学品中都含有氟,因此了解氟的化学性质将有助于设计新一代这些物质。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Dale Shellhamer其他文献
Dale Shellhamer的其他文献
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{{ truncateString('Dale Shellhamer', 18)}}的其他基金
RUI: Electrophilic Reactions of Fluorosubstituted Alkenes with Chlorosulfonyl Isocyanate and some other Electrophiles
RUI:氟代烯烃与氯磺酰异氰酸酯和其他一些亲电试剂的亲电反应
- 批准号:
0948255 - 财政年份:2010
- 资助金额:
$ 12.5万 - 项目类别:
Standard Grant
RUI: Electrophilic Reactions of Triflic Acid and Chlorosulfonyl Isocyanate with Fluorosubstituted Terminal Alkenes
RUI:三氟甲磺酸和氯磺酰异氰酸酯与氟取代末端烯烃的亲电反应
- 批准号:
0345551 - 财政年份:2004
- 资助金额:
$ 12.5万 - 项目类别:
Standard Grant
RUI: Electrophilic vs Free Radical Reactions of Halogen Systems with Terminal Perfluoroalkenes and Their Derivatives
RUI:带有末端全氟烯烃及其衍生物的卤素体系的亲电反应与自由基反应
- 批准号:
0091636 - 财政年份:2001
- 资助金额:
$ 12.5万 - 项目类别:
Standard Grant
A Mechanistic Study on the Generation of Interhalogen Fluorides and Electrophilic Additions to Perfluoroalkenes
卤间氟化物的生成及全氟烯烃的亲电加成机理研究
- 批准号:
9616442 - 财政年份:1997
- 资助金额:
$ 12.5万 - 项目类别:
Standard Grant
A Study on the Generation of Interhalogen Fluorides
卤间氟化物生成的研究
- 批准号:
9321094 - 财政年份:1994
- 资助金额:
$ 12.5万 - 项目类别:
Continuing Grant
Fluorination of Unsaturated Hydrocarbons with Xenon Difluoride
二氟化氙氟化不饱和烃
- 批准号:
8919000 - 财政年份:1990
- 资助金额:
$ 12.5万 - 项目类别:
Continuing Grant
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亲电氮制备生物活性分子的新反应
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10416714 - 财政年份:2022
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Novel Reactions of Electrophilic Nitrogen for Preparing Bioactive Molecules
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19K15559 - 财政年份:2019
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Chiral Induction in Electrophilic Substitution Reactions of Phosphenium Ions
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538294-2019 - 财政年份:2019
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Electrophilic reactions of magnesium carbenoids
类胡萝卜素镁的亲电反应
- 批准号:
18K05129 - 财政年份:2018
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$ 12.5万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
RUI: Electrophilic Reactions of Fluorosubstituted Alkenes with Chlorosulfonyl Isocyanate and some other Electrophiles
RUI:氟代烯烃与氯磺酰异氰酸酯和其他一些亲电试剂的亲电反应
- 批准号:
0948255 - 财政年份:2010
- 资助金额:
$ 12.5万 - 项目类别:
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Studies on Electrophilic Metal Complexes in Lewis Acid-Catalyzed C-C Bond-Forming Reactions
路易斯酸催化C-C键形成反应中亲电金属配合物的研究
- 批准号:
0847851 - 财政年份:2009
- 资助金额:
$ 12.5万 - 项目类别:
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CAREER: REACTIONS OF ELECTROPHILIC METAL CENTERS WITH AROMATIC HETEROCYCLES
事业:亲电金属中心与芳香杂环的反应
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0847735 - 财政年份:2009
- 资助金额:
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Reactive electrophilic intermediates of organics and bioorganic reactions
有机物和生物有机反应的反应性亲电中间体
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9922-2004 - 财政年份:2006
- 资助金额:
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Reactive electrophilic intermediates of organics and bioorganic reactions
有机物和生物有机反应的反应性亲电中间体
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9922-2004 - 财政年份:2005
- 资助金额:
$ 12.5万 - 项目类别:
Discovery Grants Program - Individual