Customized Load-Bearing Scaffolds Using Multiscale Porosity and Multi-Material Domains

使用多尺度孔隙度和多材料域的定制承重脚手架

• 批准号: 0900184
• 负责人: Amy Wagoner Johnson
• 金额: $ 43.76万
• 依托单位: University of Illinois at Urbana-Champaign
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0900184&HistoricalAwards=false
• 关键词: Customized; Load; Bearing; Scaffolds; Using

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). The research objective of this award is to develop manufacturing technology enabling the fabrication of multi-material, near net-shape tissue engineering scaffolds for bone defect repair. This will enable a new class of functionally graded scaffolds and will result in advances in the current state of the art for both rapid prototype manufacturing and bone tissue engineering research. The technology will make use of Iterative Learning Control to learn trajectories for robotic manufacturing tasks using a vision-based system. Learned functions will be stored as a library and used for constructing any arbitrary scaffold by sequencing combinations of the individual functions. The technology will enable the fabrication of novel scaffolds with 6-12 twelve combinations of macropore and micropore size and fraction in a single scaffold, which will allow for unprecedented progress in determining pore combinations that result in the fastest, most complete bone healing. The approach will require a fraction of the number of costly in vivo experiments and will obtain significantly more information in the process. If successful, the research will address a basic and growing health need in our society, namely the need for more effective options for bone defect repair. The research will also contribute to manufacture of engineered scaffolds as well as to the fundamental understanding of the role of macro and microporosities on bone ingrowth. Aspects of manufacturing and biological materials will be incorporated into the existing curriculum with the goal of making every mechanical engineering student familiar with tissue scaffolds as a design and manufacturing challenge and every bioengineering student familiar with manufacturing as an important aspect of tissue engineering. The lessons learned will be packaged for dissemination through educational channels like courses, summer camps, and undergraduate research projects, as well as through Engineering Open House, which draws thousands of visitors to campus annually.

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。该奖项的研究目标是开发制造技术，使制造多材料，近净形组织工程支架用于骨缺损修复。这将使一类新的功能梯度支架，并将导致在快速原型制造和骨组织工程研究的最新技术水平的进步。该技术将利用迭代学习控制，使用基于视觉的系统学习机器人制造任务的轨迹。学习的函数将被存储为库，并用于通过对各个函数的组合进行测序来构建任何任意支架。 该技术将能够在单个支架中制造具有6-12种大孔和微孔尺寸和分数的组合的新型支架，这将允许在确定导致最快、最完整的骨愈合的孔组合方面取得前所未有的进展。 这种方法只需要昂贵的体内实验的一小部分，并且在这个过程中将获得更多的信息。 如果成功，这项研究将解决我们社会中一个基本的和不断增长的健康需求，即需要更有效的骨缺损修复方案。 该研究还将有助于工程支架的制造以及对宏观和微观孔隙率对骨长入作用的基本理解。制造和生物材料的方面将被纳入现有的课程，使每个机械工程专业的学生熟悉组织支架作为设计和制造的挑战，每个生物工程专业的学生熟悉制造作为组织工程的一个重要方面的目标。所吸取的经验教训将通过教育渠道，如课程，夏令营和本科生研究项目，以及通过工程开放日，每年吸引成千上万的游客到校园传播。