Bio-tribo-corrosion resistant 3D Printed Composites for Load-bearing Implants

用于承重植入物的生物耐摩擦腐蚀 3D 打印复合材料

基本信息

  • 批准号:
    10631737
  • 负责人:
  • 金额:
    $ 5.49万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-08-01 至 2026-01-31
  • 项目状态:
    未结题

项目摘要

Abstract This proposed two-year diversity research supplement funding request to active National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) grant (1R01 AR078241) in response to PA- 21-071 aims to test our central hypothesis that CaP based solid lubricants in Ti or CoCrMo alloys will form an in situ films at the contact surface to minimize bio-tribo-corrosion and reduce metal ion release. The rationale is that once we understand the mechanisms of tribofilm formation and its influence on bio-tribo-corrosion, we can design implants with reduced metal ion release possibility in vivo. Our preliminary data show in situ tribofilm formation with CaP reinforcement in Ti6Al4V or CoCrMo alloys during in vitro bio-tribo-corrosion studies. The presence of tribofilm lowered wear-induced damage and minimized metal ion release in vitro. Our program will address the knowledge gap – understanding bio-tribocorrosion mechanism for surfaces with in situ formed tribofilms in CaP reinforced Ti or CoCrMo alloys to replace CoCrMo femoral head in THA. Moreover, the inherent ductility of CaP reinforced composite implants will eliminate any concerns related to the possibility of brittle fracture common in alumina-based ceramic heads that are currently being used as an alternative to CoCrMo. Our effort will also focus on translating laser-based 3D Printing (3DP) technology toward processing these novel composites. The proposed two-year diversity research supplement is requested for Dr. Jose Avila for his post- doctoral research work on 3D Printing of femoral heads using Ti6Al4V reinforced with CaP and a hard ceramic phase and test them using a hip simulator to measure both the wear-induced damage and bio- corrosion. The clinical success of this supplemental research is in manufacturing innovative femoral heads with CaP, and ceramic phase added Ti6Al4V alloy composites via 3D Printing as an alternative to pure CoCrMo. These composites will eliminate Co and Cr ions leaching due to corrosion and wear degradation from the trunnions of modular taper interlocks in THA, which leads to ALTR and early revision surgeries.
摘要 这项为期两年的多样性研究补充资金申请,以积极的国家研究所 关节炎、肌肉骨骼和皮肤疾病(NIAMS)补助金(1 R 01 AR 078241),以响应PA- 21-071旨在测试我们的中心假设,即Ti或CoCrMo合金中的CaP基固体润滑剂将 在接触表面形成原位膜以最小化生物摩擦腐蚀并减少金属离子释放。 基本原理是,一旦我们了解了摩擦膜形成的机制及其对 生物摩擦腐蚀,我们可以设计具有降低的金属离子释放可能性的植入物。我们 初步数据显示在Ti6 Al 4V或CoCrMo合金中原位形成具有CaP增强的摩擦膜 在体外生物摩擦腐蚀研究中。摩擦膜的存在降低了磨损引起的损伤, 最小化金属离子的体外释放。我们的计划将解决知识差距-理解 CaP增强Ti或CoCrMo原位形成摩擦膜表面的生物摩擦腐蚀机理 在THA中替代CoCrMo股骨头的合金。此外,CaP增强的固有延展性 复合植入物将消除任何与脆性断裂的可能性有关的担忧, 氧化铝基陶瓷股骨头目前被用作CoCrMo的替代品。我们的努力将 我还专注于将基于激光的3D打印(3DP)技术转化为处理这些新颖的 复合材料. 拟议的两年多样性研究补充要求博士何塞阿维拉为他的职位, 博士研究工作,使用CaP增强的Ti6 Al 4V和硬质合金3D打印股骨头 陶瓷相,并使用髋关节模拟器对其进行测试,以测量磨损引起的损伤和生物相容性。 腐蚀该补充研究的临床成功在于制造创新股骨部件 通过3D打印添加CaP和陶瓷相的Ti6 Al 4V合金复合材料作为替代方案 纯钴铬钼合金这些复合材料将消除钴和铬离子的浸出,由于腐蚀和磨损 THA中组配式锥体互锁的耳轴退化,导致ALTR和早期 翻修手术

项目成果

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AMIT BANDYOPADHYAY其他文献

AMIT BANDYOPADHYAY的其他文献

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{{ truncateString('AMIT BANDYOPADHYAY', 18)}}的其他基金

Bio-tribo-corrosion resistant 3D Printed Composites for Load-bearing Implants
用于承重植入物的生物耐摩擦腐蚀 3D 打印复合材料
  • 批准号:
    10331780
  • 财政年份:
    2021
  • 资助金额:
    $ 5.49万
  • 项目类别:
Bio-tribo-corrosion resistant 3D Printed Composites for Load-bearing Implants
用于承重植入物的生物耐摩擦腐蚀 3D 打印复合材料
  • 批准号:
    10772484
  • 财政年份:
    2021
  • 资助金额:
    $ 5.49万
  • 项目类别:
Bio-tribo-corrosion resistant 3D Printed Composites for Load-bearing Implants
用于承重植入物的生物耐摩擦腐蚀 3D 打印复合材料
  • 批准号:
    10565931
  • 财政年份:
    2021
  • 资助金额:
    $ 5.49万
  • 项目类别:
3D Printed Surface Modified Porous Metal Coatings for Load-bearing Implants
用于承重植入物的 3D 打印表面改性多孔金属涂层
  • 批准号:
    9314997
  • 财政年份:
    2015
  • 资助金额:
    $ 5.49万
  • 项目类别:

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