Bio-tribo-corrosion resistant 3D Printed Composites for Load-bearing Implants

摘要 这项建议为期两年的多样性研究补充资金请求现已提交给美国国立卫生研究院 关节炎、肌肉骨骼和皮肤病(NIAMS)赠款(1R01 AR078241)回应PA- 21-071旨在测试我们的中心假设，即钛或CoCrMo合金中的帽基固体润滑剂将 在接触表面形成原位薄膜，最大限度地减少生物摩擦腐蚀，减少金属离子释放。 其基本原理是，一旦我们了解了摩擦膜的形成机制及其对 生物摩擦腐蚀，我们可以设计体内金属离子释放减少的植入物。我们的 初步数据显示在Ti6Al4V或CoCrMo合金中原位形成带帽强化的摩擦膜 在体外生物摩擦腐蚀研究中。摩擦膜的存在降低了磨损诱导的损伤和 最大限度地减少金属离子的体外释放。我们的节目将解决知识差距-理解 帽状增强钛或钴铬钼原位生成摩擦膜表面的生物摩擦腐蚀机理 在全髋关节置换术中用合金替代CoCrMo股骨头。此外，帽的固有延性增强了 复合植入物将消除与常见的脆性骨折的可能性有关的任何担忧 氧化铝基陶瓷磁头，目前正被用作CoCrMo的替代品。我们的努力将 还重点介绍了将基于激光的3D打印(3DP)技术转化为处理这些新颖的 复合材料。 建议为何塞·阿维拉博士提供为期两年的多样性研究补助金，用于他的职位-- Ti6Al4V加盖硬质合金股骨头三维打印的博士研究 陶瓷相，并使用髋关节模拟器测试它们，以测量磨损诱导的损伤和生物 腐蚀。这项补充研究的临床成功在于制造了创新的股骨 带帽磁头和陶瓷相通过3D打印添加Ti6Al4V合金复合材料作为替代 到纯的CoCrMo。这些复合材料将消除由于腐蚀和磨损而导致的钴和铬离子的浸出 THA模块锥形联锁耳轴的退化，导致ALTR和早期 翻修手术。

Abstract This proposed two-year diversity research supplement funding request to active National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) grant (1R01 AR078241) in response to PA- 21-071 aims to test our central hypothesis that CaP based solid lubricants in Ti or CoCrMo alloys will form an in situ films at the contact surface to minimize bio-tribo-corrosion and reduce metal ion release. The rationale is that once we understand the mechanisms of tribofilm formation and its influence on bio-tribo-corrosion, we can design implants with reduced metal ion release possibility in vivo. Our preliminary data show in situ tribofilm formation with CaP reinforcement in Ti6Al4V or CoCrMo alloys during in vitro bio-tribo-corrosion studies. The presence of tribofilm lowered wear-induced damage and minimized metal ion release in vitro. Our program will address the knowledge gap – understanding bio-tribocorrosion mechanism for surfaces with in situ formed tribofilms in CaP reinforced Ti or CoCrMo alloys to replace CoCrMo femoral head in THA. Moreover, the inherent ductility of CaP reinforced composite implants will eliminate any concerns related to the possibility of brittle fracture common in alumina-based ceramic heads that are currently being used as an alternative to CoCrMo. Our effort will also focus on translating laser-based 3D Printing (3DP) technology toward processing these novel composites. The proposed two-year diversity research supplement is requested for Dr. Jose Avila for his post- doctoral research work on 3D Printing of femoral heads using Ti6Al4V reinforced with CaP and a hard ceramic phase and test them using a hip simulator to measure both the wear-induced damage and bio- corrosion. The clinical success of this supplemental research is in manufacturing innovative femoral heads with CaP, and ceramic phase added Ti6Al4V alloy composites via 3D Printing as an alternative to pure CoCrMo. These composites will eliminate Co and Cr ions leaching due to corrosion and wear degradation from the trunnions of modular taper interlocks in THA, which leads to ALTR and early revision surgeries.