Bio-tribo-corrosion resistant 3D Printed Composites for Load-bearing Implants

用于承重植入物的生物耐摩擦腐蚀 3D 打印复合材料

• 批准号: 10631737
• 负责人: AMIT BANDYOPADHYAY
• 金额: $ 5.49万
• 依托单位: WASHINGTON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10631737
• 关键词: 3D Print; Address; Alloys; Aluminum Oxide; Ceramics; Clinical; Corrosion; Data; Film; Fracture; Funding; Grant; Head; Hip region structure; Implant; In Situ; In Vitro; Ions; Knowledge; Lasers; Lubricants; Measures; Metals; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Operative Surgical Procedures; Phase; Postdoctoral Fellow; Psychological reinforcement; Research; Resistance; Solid; Surface; Technology; Testing; Translating; Weight-Bearing state; Work; base; ductile; implant design; in vivo; innovation; novel; programs; response; success

Abstract This proposed two-year diversity research supplement funding request to active National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) grant (1R01 AR078241) in response to PA- 21-071 aims to test our central hypothesis that CaP based solid lubricants in Ti or CoCrMo alloys will form an in situ films at the contact surface to minimize bio-tribo-corrosion and reduce metal ion release. The rationale is that once we understand the mechanisms of tribofilm formation and its influence on bio-tribo-corrosion, we can design implants with reduced metal ion release possibility in vivo. Our preliminary data show in situ tribofilm formation with CaP reinforcement in Ti6Al4V or CoCrMo alloys during in vitro bio-tribo-corrosion studies. The presence of tribofilm lowered wear-induced damage and minimized metal ion release in vitro. Our program will address the knowledge gap – understanding bio-tribocorrosion mechanism for surfaces with in situ formed tribofilms in CaP reinforced Ti or CoCrMo alloys to replace CoCrMo femoral head in THA. Moreover, the inherent ductility of CaP reinforced composite implants will eliminate any concerns related to the possibility of brittle fracture common in alumina-based ceramic heads that are currently being used as an alternative to CoCrMo. Our effort will also focus on translating laser-based 3D Printing (3DP) technology toward processing these novel composites. The proposed two-year diversity research supplement is requested for Dr. Jose Avila for his post- doctoral research work on 3D Printing of femoral heads using Ti6Al4V reinforced with CaP and a hard ceramic phase and test them using a hip simulator to measure both the wear-induced damage and bio- corrosion. The clinical success of this supplemental research is in manufacturing innovative femoral heads with CaP, and ceramic phase added Ti6Al4V alloy composites via 3D Printing as an alternative to pure CoCrMo. These composites will eliminate Co and Cr ions leaching due to corrosion and wear degradation from the trunnions of modular taper interlocks in THA, which leads to ALTR and early revision surgeries.

抽象的 这项提议向活跃的国家研究所提出了为期两年的多样性研究补充资金请求 关节炎、肌肉骨骼和皮肤疾病 (NIAMS) 拨款 (1R01 AR078241) 响应 PA- 21-071 旨在检验我们的中心假设，即 Ti 或 CoCrMo 合金中的 CaP 基固体润滑剂将 在接触表面形成原位薄膜，以最大限度地减少生物摩擦腐蚀并减少金属离子释放。 基本原理是，一旦我们了解了摩擦膜形成的机制及其对 生物摩擦腐蚀，我们可以设计减少体内金属离子释放可能性的植入物。我们的 初步数据显示，Ti6Al4V 或 CoCrMo 合金中通过 CaP 强化形成原位摩擦膜 在体外生物摩擦腐蚀研究期间。摩擦膜的存在降低了磨损引起的损坏 最大限度地减少体外金属离子的释放。我们的计划将解决知识差距——理解 CaP 增强 Ti 或 CoCrMo 中原位形成摩擦膜表面的生物摩擦腐蚀机制 合金在 THA 中替代 CoCrMo 股骨头。此外，CaP 固有的延展性增强了 复合植入物将消除与常见的脆性断裂可能性相关的任何担忧 氧化铝基陶瓷头目前被用作 CoCrMo 的替代品。我们的努力将 还专注于将基于激光的 3D 打印 (3DP) 技术转化为加工这些新颖的材料 复合材料。 为 Jose Avila 博士申请了拟议的两年多样性研究补充，以供他在 使用CaP和硬质合金增强Ti6Al4V进行股骨头3D打印的博士研究工作 陶瓷相并使用髋关节模拟器对其进行测试，以测量磨损引起的损伤和生物损伤 腐蚀。这项补充研究的临床成功在于制造创新的股骨 带有 CaP 的头部，以及通过 3D 打印添加陶瓷相的 Ti6Al4V 合金复合材料作为替代方案 至纯钴铬钼。这些复合材料将消除因腐蚀和磨损而浸出的钴和铬离子 THA 中模块化锥度互锁耳轴的退化，导致 ALTR 和早期 翻修手术。