Ca2+-dependent CTL and NK cell cytotoxicity (A01)

细胞毒性T淋巴细胞（CTL）和自然杀伤（NK）细胞与肿瘤细胞形成密切接触。我们已经表明，CTL和NK细胞杀死肿瘤细胞最有效的接触过程中形成在一个令人惊讶的低胞质Ca 2+浓度。我们将分析这一过程的分子机制。考虑到CTL和NK细胞在癌症细胞免疫治疗中的重要性，我们将筛选具有调节Ca 2+依赖性细胞毒性能力的天然化合物。最后，我们将分析Ca2+在人类细胞毒性疾病中的作用。

Cytotoxic T lymphocytes (CTL) and Natural Killer (NK) cells form intimate contacts with tumor cells. We have shown that CTL and NK cells kill tumor cells most efficiently during contact formation at a surprisingly low cytosolic Ca2+ concentration. We will analyze the molecular mechanisms of this process. Considering the importance of CTL and NK cells in cellular immune therapy of cancer, we will screen natural compounds for their ability to modulate Ca2+-dependent cytotoxicity. Finally, we will analyze the role of Ca2+ in human cytotoxicity diseases.