Theoretical and experimental analyses of neural circuits that control intersegmental differences in phase

控制节间相位差异的神经回路的理论和实验分析

• 批准号: 0905063
• 负责人: Brian Mulloney
• 金额: $ 96.34万
• 依托单位: University of California-Davis
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2014-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0905063&HistoricalAwards=false
• 关键词: Theoretical; experimental; analyses; neural; circuits

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).A major goal of neuroscience is to understand the dynamics of neural circuits. In most circuits, ignorance of intrinsic neural properties and synaptic organization limits our ability to understand the performance. This project exploits new discoveries of the synaptic organization of a circuit that coordinates limb movements during locomotion. An integrated program of experimental neurophysiology and mathematical theory will be used to explain how dynamics emerge from the interactions of intrinsic neuronal properties, synaptic dynamics, and synaptic organization. Using coupled-oscillator theory to guide neurophysiological experiments, and experimental results to constrain development of new models, a model of the circuit will be constructed and used to explore how intrinsic properties of different neurons and synaptic connectivity combine to produce the stable differences in phase of limb movements that are essential for effective locomotion. This modeling work will search for general principles governing dynamics in coordinating circuits. Because these circuits are central to many neural systems, the results should be applicable to many different systems. Many components of this project lend themselves well to undergraduate research. Undergraduate students will be heavily involved in summer research programs and Senior Honors Thesis projects. To augment their introduction to research, an advanced undergraduate course will focus on weekly research seminars by speakers who are successful members of underrepresented groups, followed by lunch and discussion with the speaker. To hone their presentation and communication skills, students will be encouraged to present their work in the departmental mathematical biology seminar series. Students will also be recruited from UC Davis REU programs that support students from economically disadvantaged backgrounds or from under-represented groups.

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。神经科学的一个主要目标是了解神经回路的动力学。 在大多数电路中，对内在神经特性和突触组织的无知限制了我们理解性能的能力。 该项目利用了在运动过程中协调肢体运动的回路的突触组织的新发现。 一个实验神经生理学和数学理论的综合方案将被用来解释动态如何从内在神经元特性，突触动力学和突触组织的相互作用。 使用耦合振荡器理论来指导神经生理学实验，并使用实验结果来约束新模型的开发，将构建电路的模型并用于探索不同神经元的固有特性和突触连接性如何结合联合收割机来产生有效运动所必需的肢体运动相位的稳定差异。 这项建模工作将寻求协调电路中动态的一般原则。 由于这些回路是许多神经系统的核心，因此这些结果应该适用于许多不同的系统。 这个项目的许多组成部分很适合本科生的研究。 本科生将积极参与暑期研究项目和高级荣誉论文项目。 为了增加他们对研究的介绍，一个先进的本科课程将侧重于每周的研究研讨会，由发言者谁是代表性不足的群体的成功成员，然后与发言者午餐和讨论。 为了磨练他们的演讲和沟通技巧，学生将被鼓励提出他们的工作在部门数学生物学研讨会系列。 学生还将从加州大学戴维斯分校REU计划招募，这些计划支持来自经济弱势背景或代表性不足的群体的学生。