Multifunctional Biomaterials from Collagen-Containing Multiblock Polymers

来自含胶原多嵌段聚合物的多功能生物材料

• 批准号: 0907478
• 负责人: Kristi Kiick
• 金额: $ 42万
• 依托单位: University of Delaware
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-15 至 2015-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0907478&HistoricalAwards=false
• 关键词: Multifunctional; Biomaterials; Collagen; Containing; Multiblock

This award by the Biomaterials program in the Division of Materials Research to University of Delaware is to develop new collagen-domain-containing, elastomeric multiblock copolymers that will be capable of multiple orders of assembly triggered by environmental cues such as temperature, pH, and metal ion concentration. The development of materials functionalized with peptide and polypeptide domains offers important opportunities for detailed control of the assembly, responsiveness, and function of hybrid materials. Accordingly, a variety of polypeptides comprising the putative repeat sequences of natural structural proteins have been produced with useful applications in nanotechnology and medicine. This research project is to identify new sequences and strategies for the bacterial expression of functional collagen polypeptides, as well as their recombinant incorporation into elastin-collagen-elastin triblock copolypeptides. The main objectives of this project are: a) Recombinant expression of new hydrophilic collagen-like polypeptides and characterization of their triple-helix formation; b) Production of stimuli-responsive triblock and multiblock copolymers comprising thermally responsive elastin-like domains and collagen-like domains; and c) Characterization and elaboration of the materials after their assembly.Basic understanding of the programmed sequential assembly, functionalized with peptide and polypeptide domains, will offer unprecedented opportunities to produce materials with desired assembled structures and subsequent control over the presentation of biologically, electrically, and optically active moieties. Elaboration of these structures with organic and inorganic groups will offer materials that can function as adhesives, tough wound healing materials, cell-adherent tissue scaffolds, and optically active layers in devices. The proposed academic programs include teaching and training of students from underrepresented groups including women in the proposed research activities. ?The Science of Art?, an outreach program as part of this award, will present the science of materials and their properties at art classes to students at secondary level and engage them in scientific concepts in an environment outside of that in which science learning normally occurs.

该奖项由特拉华大学材料研究部的生物材料项目授予，旨在开发新型胶原域、弹性体多嵌段共聚物，这种聚合物将能够根据环境提示(如温度、pH和金属离子浓度)触发多个顺序的组装。多肽和多肽结构域功能化材料的发展为杂化材料的组装、响应性和功能的详细控制提供了重要的机会。因此，由天然结构蛋白的假定重复序列组成的各种多肽已被生产出来，在纳米技术和医学中具有有用的应用。本研究旨在为功能性胶原多肽的细菌表达及其在弹性蛋白-胶原-弹性蛋白三嵌段共聚肽中的重组整合寻找新的序列和策略。该项目的主要目标是：a)重组表达新的亲水性胶原蛋白样多肽并表征其三螺旋结构；b)生产包括热响应性弹性蛋白样结构域和胶原样结构域的刺激响应性三嵌段和多嵌段共聚物；以及c)材料组装后的表征和精加工。通过对具有多肽和多肽结构域功能化的程序化顺序组装的基本了解，将提供前所未有的机会来制造具有所需组装结构的材料，并随后控制生物活性、电活性和光学活性部分的呈现。这些结构的有机和无机基团的精加工将提供可用作粘合剂、坚韧的伤口愈合材料、细胞黏附组织支架和设备中的光学活性层的材料。拟议的学术方案包括在拟议的研究活动中对包括妇女在内的代表性不足群体的学生进行教学和培训。？艺术科学？，作为该奖项的一部分，将在中学阶段的艺术课上向学生介绍材料科学及其性质，并让他们在正常情况下进行科学学习的环境之外的环境中接触科学概念。