Directing nanoscale assembly of peptide-containing multiblock polymers

指导含肽多嵌段聚合物的纳米级组装

• 批准号: 1213728
• 负责人: Kristi Kiick
• 金额: $ 58万
• 依托单位: University of Delaware
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-15 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1213728&HistoricalAwards=false
• 关键词: Directing; nanoscale; assembly; peptide; containing

In this project funded by the Macromolecular, Supramolecular and Nanochemistry Program of the Chemistry Division, Professors Kristi Kiick, Xinqiao Jia, and Christopher Roberts of the University of Delaware will employ a combination of computational, synthetic, and advanced characterization methods to elucidate the molecular design rules for the assembly of peptide-polymer nanostructures. Coarse-grained computational models will be used to reveal the molecular details of the association behavior of various structurally relevant peptides, both alone and in the context of hydrophilic polymer domains of various lengths. Molecules that are indicated to adopt diverse nanostructured assemblies will be synthesized. A combination of spectrophotometric, calorimetric, scattering, and microscopy methods will be used to characterize assembly and aggregation, with correlation to the molecular details of the peptide association. This research will provide new synthetic pathways to access these novel macromolecular structures and will establish the rules that govern assembly on the basis of multiple and controllable stimuli. The broader impacts involve broad, multidisciplinary training of graduate and undergraduate students, participation in the University of Delaware College of Engineering K-12 Outreach Program (including the creation of new activities within this infrastructure), and the potential societal benefits of a fundamental understanding of the assembly of polymer-peptide conjugates.Peptides are chains of chemically linked amino acids and are the components of proteins. This work will expand the repertoire of chemistry that can be used to create new large molecules that mimic natural biomaterials and will lead to a better understanding of how peptides aggregate into larger structures. Such aggregation phenomena are linked to the inactivation of biopharmaceuticals and the progression of neurodegenerative diseases. This research could have long term applications in medicine, pharmaceutical processing, and nanotechnology.

在这个由化学系高分子、超分子和纳米化学项目资助的项目中，特拉华大学的 Kristi Kiick、Xinqiao Jia 和 Christopher Roberts 教授将采用计算、合成和先进表征方法的组合来阐明肽-聚合物纳米结构组装的分子设计规则。粗粒度计算模型将用于揭示各种结构相关肽的关联行为的分子细节，无论是单独的还是在不同长度的亲水性聚合物结构域的背景下。 将合成表明采用不同纳米结构组件的分子。 将使用分光光度、量热、散射和显微镜方法的组合来表征组装和聚集，并与肽缔合的分子细节相关。这项研究将提供新的合成途径来获得这些新颖的大分子结构，并将建立基于多重可控刺激的组装规则。 更广泛的影响包括对研究生和本科生进行广泛的多学科培训、参与特拉华大学工程学院 K-12 外展计划（包括在该基础设施内创建新活动），以及对聚合物-肽缀合物组装的基本了解所带来的潜在社会效益。肽是化学连接的氨基酸链，是蛋白质的组成部分。 这项工作将扩展化学库，可用于创建模仿天然生物材料的新大分子，并将更好地理解肽如何聚集成更大的结构。 这种聚集现象与生物药物的失活和神经退行性疾病的进展有关。 这项研究可以在医学、药物加工和纳米技术方面具有长期应用。