Transition Metal-Mediated Construction of Novel Molecules

过渡金属介导的新型分子构建

• 批准号: 0907800
• 负责人: K. Peter Vollhardt
• 金额: $ 79.59万
• 依托单位: University of California-Berkeley
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2013-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0907800&HistoricalAwards=false
• 关键词: Transition; Metal; Mediated; Construction; Novel

This project aims to use transition metals, in particular cobalt complexes, for the development of methodology for the rapid construction of novel complex molecules by multiple bond formation. These include the phenylenes, a new class of novel cyclohexatrienoid hydrocarbons endowed with strain and antiaromatic activation. These molecules are not only adding fundamental knowledge to the understanding of aromatic delocalization, but also have great promise in applications such as thin film transistors, organic semiconductor materials, electroluminescent devices, energy storage systems, and others. A long term goal is to facilitate the invention of integrated nanotechnologies for the microsystems of the future. In another thrust, the synthetic methodology to be developed under this program should facilitate the construction of hitherto inaccessible novel compound classes of synthetic and medicinal interest. Through the understanding of mechanisms, and aided by computational methods, catalytic selectivity will be sought. This effort should greatly simplify routes to natural and unnatural products, with impact on total synthesis and the development of compound libraries endowed with new potentially pharmacophoric motifs. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor K. Peter C Vollhardt of the Department of Chemistry at the University of California at Berkeley. Professor Vollhardt's research efforts focus on the development of transition metal mediated transformations that lead to novel molecules. His efforts could positively impact materials, energy, and medical research.

该项目旨在利用过渡金属，特别是钴络合物，开发通过多重键形成快速构建新型络合物分子的方法。 这些包括亚苯基，一类新的新型环己三烯烃赋予应变和反芳烃活化。 这些分子不仅增加了对芳香离域的理解的基础知识，而且在诸如薄膜晶体管、有机半导体材料、电致发光器件、能量存储系统等应用中具有很大的前景。 一个长期目标是促进为未来的微系统发明集成纳米技术。在另一个推力下，该计划下开发的合成方法应有助于构建迄今为止无法实现的具有合成和药用价值的新型化合物。 通过对机理的理解，并借助于计算方法，将寻求催化选择性。 这一努力将大大简化天然和非天然产物的路线，对全合成和开发具有新的潜在药效基序的化合物库产生影响。 有了这个奖项，有机和高分子化学计划是支持K教授的研究。加州大学伯克利分校化学系的Peter C Vollhardt说。 Vollhardt教授的研究重点是过渡金属介导的转化，导致新的分子的发展。 他的努力可能会对材料、能源和医学研究产生积极影响。