U.S.-France Cooperative Research: A Cobalt-Mediated Total Synthesis of the Antiviral Aphidicolin

美法合作研究：钴介导的抗病毒阿菲迪霉素全合成

• 批准号: 8715883
• 负责人: K. Peter Vollhardt
• 金额: $ 0.95万
• 依托单位: University of California-Berkeley
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-03-01 至 1990-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8715883&HistoricalAwards=false
• 关键词: U.S.; France; Cooperative; Research; Cobalt

This award will support collaborative research between Prof. K.P.C. Vollhardt of the University of California, Berkeley, and Dr. Max Malacria of the Universite de Lyon, France, in the area of the synthesis of antiviral antibiotics. In particular, the project is aimed at the total synthesis of the antiviral Aphidicolin. Because of its antiviral and antineoplastic properties, the versatile, short, and efficient construction of this molecule has considerable synthetic and medicinal significance. The goal of this work is to compare alternative approaches to the synthesis of this antibiotic developed by the two collaborators. In both approaches, cobalt is used as a catalyst to unravel the organo-molecular structures of the starting material. However, the mid-points of the process, in which new molecular structures are formed, are conceptually different and follow different sequences of molecular formation and breakage. The U.S. and French researchers have worked together in the past; this award will facilitate increased interaction between their respective laboratories. Comparing the two approaches to the synthesis of Aphidicolin will provide important new insights into the scope and limitations of both methods.

该奖项将支持加州大学伯克利分校的K.P.C.Vollhardt教授和法国里昂大学的Max Malacria博士在抗病毒抗生素合成领域的合作研究。特别是，该项目的目标是抗病毒Aphidicolin的全合成。由于其抗病毒和抗肿瘤的特性，该分子的多用途、短和有效的结构具有相当大的合成和医学意义。这项工作的目标是比较两位合作者开发的合成这种抗生素的替代方法。在这两种方法中，钴都被用作催化剂来分解起始材料的有机分子结构。然而，形成新分子结构的过程的中间点在概念上是不同的，遵循不同的分子形成和破坏顺序。美国和法国的研究人员过去曾合作过；这一奖项将促进各自实验室之间加强互动。比较这两种方法的合成将对这两种方法的范围和局限性提供重要的新见解。