U.S.-France Cooperative Research: A Cobalt-Mediated Total Synthesis of the Antiviral Aphidicolin

该奖项将支持合作研究， K.P.C.教授沃尔哈特大学 加州，伯克利，和博士马克斯Malacria的 法国里昂大学 抗病毒抗生素的合成。特别是 该项目旨在全面综合 抗病毒蚜虫菌素。 由于其抗病毒和 性能优异，用途广泛， 这种分子的高效构建 具有重要的合成和药用价值。 这项工作的目标是比较替代 这种抗生素的合成方法 由两位合作者开发。 无论是 钴被用作催化剂， 起始物的有机分子结构 材料 然而，在这一进程的中点， 形成新的分子结构， 概念不同，遵循不同的顺序 分子的形成和断裂。 美国和法国的研究人员共同努力， 在过去，这一奖项将有助于增加 他们各自的实验室之间的互动。 比较了两种合成方法， Aphidicolin将提供重要的新见解， 这两种方法的范围和局限性。

This award will support collaborative research between Prof. K.P.C. Vollhardt of the University of California, Berkeley, and Dr. Max Malacria of the Universite de Lyon, France, in the area of the synthesis of antiviral antibiotics. In particular, the project is aimed at the total synthesis of the antiviral Aphidicolin. Because of its antiviral and antineoplastic properties, the versatile, short, and efficient construction of this molecule has considerable synthetic and medicinal significance. The goal of this work is to compare alternative approaches to the synthesis of this antibiotic developed by the two collaborators. In both approaches, cobalt is used as a catalyst to unravel the organo-molecular structures of the starting material. However, the mid-points of the process, in which new molecular structures are formed, are conceptually different and follow different sequences of molecular formation and breakage. The U.S. and French researchers have worked together in the past; this award will facilitate increased interaction between their respective laboratories. Comparing the two approaches to the synthesis of Aphidicolin will provide important new insights into the scope and limitations of both methods.