DISSERTATION RESEARCH: Genetics of a hybrid incompatibility between Drosophila mauritiana and its sibling species

论文研究：毛里求斯果蝇与其兄弟物种之间杂种不亲和性的遗传学

• 批准号: 0909382
• 负责人: Daven Presgraves
• 金额: $ 1.14万
• 依托单位: University of Rochester
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0909382&HistoricalAwards=false
• 关键词: DISSERTATION; RESEARCH; Genetics; hybrid; incompatibility

Species are populations of interbreeding individuals that are reproductively incompatible with other populations. Therefore, the genes that cause reproductive incompatibility, so-called 'speciation genes', provide the genetic basis of the origin of new species. The aim of this project is to map and identify speciation genes involved in reproductive incompatibility between three fruitfly species that diverged from one another ~250,000 years ago: Drosophila simulans, D. sechellia and D. mauritiana. The work focuses on mapping and characterizing two incompatible speciation genes: a factor on the D. mauritiana X chromosome, called hlx, kills hybrids when combined with an incompatible autosomal factor from D. simulans and D. sechellia, called Suppressor of hlx. The identification and molecular characterization of speciation genes will answer long-standing questions about the genetic forces involved in the early stages of species diversification. This project includes training and participation of undergraduate students, as well as the continuing participation of the investigators in public outreach in their local community.

物种是与其他种群繁殖不相容的杂交个体的种群。因此，导致生殖不相容的基因，即所谓的“物种形成基因”，为新物种的起源提供了遗传基础。该项目的目的是绘制和鉴定大约25万年前彼此分化的三种果蝇（拟果蝇、D. sechellia和D. mauritiana）之间生殖不相容的物种形成基因。这项工作的重点是绘制和描述两个不相容的物种形成基因：毛里求斯蜥蜴X染色体上的一个因子，称为hlx，当与来自拟象蜥蜴和蜥蜴的一个不相容的常染色体因子，称为hlx抑制因子结合时，会杀死杂交后代。物种形成基因的鉴定和分子特征将回答关于物种多样化早期阶段涉及的遗传力量的长期问题。该项目包括对本科生的培训和参与，以及调查人员继续参与当地社区的公共宣传。