Guanidine Rich Synthetic Macromolecules-Transduction Domain Mimics

美国国家科学基金会化学部的有机和大分子化学项目支持马萨诸塞大学阿默斯特分校的Gregory Tew教授，他的研究将开发一种具有强穿透细胞活性的新型仿生聚合物。初步的工作已经证明了构建细胞穿透肽或蛋白质转导域模拟物的能力。所提出的全面的构效关系对于获得新的见解和理解这些独特分子的行为奠定了基础至关重要。这项工作将探讨高分子化学和膜转导活性之间的基本概念。而且，由于这些分子穿过磷脂膜，将获得关于分子如何与这一至关重要的生物屏障结合和移动的新见解。Tew教授的研究将最先进的有机和聚合物化学与跨膜易位相结合，并提供了开发穿越生物细胞膜屏障的非肽分子的机会。这将在药物和非病毒基因传递方面有重要的应用，也为学习如何靶向细胞内的膜奠定了基础。在这个多学科计划中训练的学生将成为能够跨传统学科工作的年轻科学家。Tew教授是全国黑人化学家和化学工程师专业发展组织（NOBCChE）全国会议的积极参与者。他在2006年全国会议上主持了一个名为“登陆你的第一个终身教职”的研讨会，最近被任命为技术编程委员会成员。这次成功的研讨会再次安排在2009年年会。2005年，马萨诸塞大学阿姆赫斯特分校的聚合物科学与工程学院（PSE）建立了一个同侪指导项目，该项目得到了全校的认可。目前的提案将整合到这些正在进行的活动中，特别是将作为NOBCChE学生，NOBCChE社区和专注于知识产权和科学的行业之间的新研讨会的平台。已经提交了一份临时专利申请，涵盖本提案中讨论的材料。它将被用作NOBCChE学生参与“翻译研究”主题的平台。

The Organic and Macromolecular Chemistry Program in the Chemistry Division at the National Science Foundation supports Professor Gregory Tew of the University of Massachusetts Amherst whose research will develop a novel class of biomimetic polymers with potent cell-penetrating activity. Preliminary work has demonstrated the ability to build cell-penetrating peptide, or protein transduction domain mimics. The comprehensive structure-activity relationship proposed is essential for gaining novel insight and laying a foundation for understanding the behavior of these unique molecules. This work will probe fundamental concepts between polymer chemistry and membrane transduction activity. And, since these molecules traverse the phospholipid membrane, new insights will be gained on how molecules bind with and move across this critically important biological barrier.Research by Professor Tew combines state of the art organic and polymer chemistry with translocation across membranes and provides the opportunity to develop non-peptidic molecules that traverse the biological cell membrane barrier. This will have important applications in drug and non-viral gene delivery and also lay the foundation for learning how to target membranes within cells. Students trained within this multi-disciplinary proposal will become young scientists who are able to work across traditional disciplines. Professor Tew is an active participant in the National Organization for the Professional Advancement of Black Chemists and Chemical Engineers (NOBCChE) National Meetings. He conducted a workshop entitled "Landing Your First Tenure Track Faculty Position" at the 2006 National Meeting and was recently appointed to the technical programming committee. This successful workshop was scheduled again for the 2009 Annual Meeting. A peer-mentoring program was established within Polymer Science and Engineering (PSE) at the University of Massachusetts Amherst in 2005 which has received campus-wide recognition. The current proposal will be integrated into these on-going activities and specifically will be used as a platform for a new workshop at NOBCChE between students, the NOBCChE community, and industry focused on intellectual property and science. A provisional patent application has been filed covering the materials discussed in this proposal. It will be used as the platform to engage NOBCChE students in the topic of "translational research".