De Novo Design of Protein Transduction Domain Mimics Enabling New Opportunities

蛋白质转导域模拟物的从头设计带来新机遇

• 批准号: 1308123
• 负责人: Gregory Tew
• 金额: $ 44万
• 依托单位: University of Massachusetts Amherst
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2018-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1308123&HistoricalAwards=false
• 关键词: De; Novo; Design; Protein; Transduction

This award by the Biomaterials program in the Division of Materials Research to University of Massachusetts Amherst is in developing an understanding of the fundamental connections between polymer chemistry and biomembrane transduction activity. This project is cofunded by the Biotechnology, Biochemical, and Biomass Engineering program in the Division of Chemical, Bioengineering, Environmental, and Transport Systems. Learning to build simple polymeric structures with protein-like activity is a critically important goal of modern science. Comprehensive structure-activity relationships will be essential for gaining novel insights and laying a foundation for understanding the mechanistic origins of these unique molecules. Because these molecules transverse the phospholipid membranes, new insights will be gained on how molecules bind with and move across this critically important biological barrier. This project combines state-of-the-art organic and polymer chemistry with translocation and delivery across biological membranes. Educating and training students within this multi-disciplinary proposal will prepare these young scientists with a broad technical background ready to work across traditional disciplines to join the modern workforce.Research is the engine that has driven and will continue to drive the U.S. economy. As a result, continued and growing investments in fundamental discoveries remain essential. This current proposal focuses on discoveries at the interface of organic chemistry, polymer science, and biology. Using natural systems for inspiration, a novel series of synthetic molecules will be designed that capture the essential features of these natural systems. In the long run, research like this will impact many fields of science and lead to new fundamental knowledge at the interface of materials science and biology. This project will also train graduate students and serve as advanced training for post-doctoral fellows. With experience spanning from organic chemistry to cell culture, students will be trained broadly to revolutionize the American workforce. Specific efforts will focus on continuing to broaden the participation of underrepresented minorities to ensure we utilize all of our countries talent.

该奖项由马萨诸塞州阿默斯特大学材料研究部的生物材料项目授予，旨在了解聚合物化学与生物膜转导活性之间的基本联系。该项目由化学，生物工程，环境和运输系统部门的生物技术，生物化学和生物质工程项目共同资助。学习构建具有蛋白质样活性的简单聚合物结构是现代科学的一个至关重要的目标。全面的结构-活性关系对于获得新的见解和为理解这些独特分子的机制起源奠定基础至关重要。由于这些分子穿过磷脂膜，因此将获得关于分子如何与这一至关重要的生物屏障结合并穿过这一屏障的新见解。该项目将最先进的有机和聚合物化学与跨生物膜的转运和递送相结合。教育和培训学生在这个多学科的建议将准备这些年轻的科学家与广泛的技术背景准备跨传统学科的工作，加入现代劳动力。研究是驱动的引擎，并将继续推动美国经济。因此，对基础发现的持续和不断增加的投资仍然至关重要。目前的建议集中在有机化学，聚合物科学和生物学的界面上的发现。利用自然系统的灵感，将设计一系列新颖的合成分子，以捕捉这些自然系统的基本特征。从长远来看，这样的研究将影响许多科学领域，并在材料科学和生物学的界面上产生新的基础知识。该项目还将培训研究生，并作为博士后研究员的高级培训。从有机化学到细胞培养的经验，学生将接受广泛的培训，以彻底改变美国的劳动力。具体的努力将侧重于继续扩大代表性不足的少数民族的参与，以确保我们利用我们所有国家的人才。