New Methods to Prepare Carbon-Heteroatom and Carbon-Carbon Bonds

制备碳-杂原子和碳-碳键的新方法

• 批准号: 0911017
• 负责人: Janis Louie
• 金额: $ 42万
• 依托单位: University of Utah
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0911017&HistoricalAwards=false
• 关键词: New; Methods; Prepare; Carbon; Heteroatom

This proposal encompasses the preparation of a variety of cyclic and acyclic compounds from environmentally friendly and readily available starting materials. The Louie's laboratory recently discovered a potentially important intermediate in Ni-catalyzed cross-coupling reactions. Mechanistic analysis of both cycloaddition reactions as well as cross-coupling reactions will be continued. Concurrent to these investigations, reactive M-CO2 intermediates will be synthesized and their reactivity toward other substrates will be explored with the intention of incorporating these reactivity patterns into the repertoire of new catalytic reactions.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Janis Louie of the Department of Chemistry at the University of Utah. Professor Louie's research efforts revolve around the development of facile transition metal-mediated methods for the formation of cyclic and acyclic compounds. In addition, new methods for utilizing benign starting materials such as carbon dioxide will be evaluated. Successful development of the methodology will have an impact on synthesis in the pharmaceutical and agricultural industries.

本提案包括从环境友好和现成的起始材料制备各种环和非环化合物。路易的实验室最近在镍催化的交叉偶联反应中发现了一种潜在的重要中间体。环加成反应和交叉偶联反应的机理分析将继续进行。在这些研究的同时，反应性M-CO2中间体将被合成，它们对其他底物的反应性将被探索，目的是将这些反应模式纳入新的催化反应库。通过这个奖项，有机和大分子化学项目支持犹他大学化学系的詹尼斯·路易教授的研究。路易教授的研究工作围绕着易过渡金属介导的方法形成环和非环化合物的发展。此外，将评估利用二氧化碳等良性起始材料的新方法。该方法的成功发展将对制药和农业工业的合成产生影响。