NEW METHODS TO PREPARE CARBON-HETEROATOM AND CARBON-CARBON BONDS

制备碳杂原子和碳碳键的新方法

• 批准号: 1213774
• 负责人: Janis Louie
• 金额: $ 44.1万
• 依托单位: University of Utah
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-15 至 2015-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1213774&HistoricalAwards=false
• 关键词: NEW; METHODS; PREPARE; CARBON; HETEROATOM

With this award, the Chemical Synthesis program is supporting the research of Professor Janis Louie of the Department of Chemistry at the University of Utah. This project focuses on the preparation of a variety of cyclic and acyclic compounds from environmentally friendly and readily available starting materials. Previously, transition metal catalysts that mediate the cycloaddition of unsaturated hydrocarbons and heterocumulenes had been developed in Professor Louie's laboratory. This project focuses on the elucidation of the mechanism of these cycloaddition reactions in order to develop more efficient metal-mediated reactions. Expanding the scope of these metal catalyzed cycloaddition reactions will also be a focus. In addition, further studies of a recently discovered important intermediate in Ni-catalyzed cross-coupling reactions will be pursued. Professor Louie's research efforts revolve around the development of facile transition metal-mediated methods for the formation of cyclic and acyclic compounds. In addition, new methods for utilizing benign starting materials will be evaluated. Successful development of the methodology will have an impact on any area of activity in which the synthesis of molecules is needed, such as the pharmaceutical, chemical, agricultural industry, and biological and chemical research. In addition, this project will provide training opportunities for students from the pre-undergraduates to post-doctoral level.

通过这个奖项，化学合成计划支持犹他大学化学系的Janis Louie教授的研究。该项目的重点是从环境友好和容易获得的原料中制备各种环状和非环状化合物。此前，路易教授的实验室已经开发出了用于不饱和碳氢化合物和杂立方烯环加成反应的过渡金属催化剂。本项目致力于阐明这些环加成反应的机理，以开发更有效的金属介导的反应。扩大这些金属催化的环加成反应的范围也将是一个焦点。此外，对最近发现的镍催化交叉偶联反应中的重要中间体的进一步研究也将继续进行。路易教授的研究工作围绕着开发简便的过渡金属介导的方法来形成环状和非环状化合物。此外，还将评估利用无害起始材料的新方法。方法学的成功发展将对任何需要合成分子的活动领域产生影响，例如制药、化学、农业以及生物和化学研究。此外，该项目将为学生提供从本科前期到博士后水平的培训机会。