Synthesis, Reactivity and Mechanisms of Group 4 Metallocene Catalysts

第4族茂金属催化剂的合成、反应活性及机理

• 批准号: 0911180
• 负责人: Richard Jordan
• 金额: $ 61.6万
• 依托单位: University of Chicago
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2013-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0911180&HistoricalAwards=false
• 关键词: Synthesis; Reactivity; Mechanisms; Group; Metallocene

The Inorganic, Bioinorganic and Organometallic Chemistry Program supports the research of Professor Richard F. Jordan of the University of Chicago to design general methods for the syntheses of enantiopure group 4 metallocenes and libraries of the new catalysts for applications in asymmetric catalysis. The new chiral metallocenes enable the development of new catalytic, stereoselective C-H functionalization reactions that can be applied in organic syntheses and in the syntheses of novel polymers that contain heterocycles in the main chain. The studies of the d0-metal alkene and alkyne complexes provide new insights to the structures, thermodynamics, kinetics, dynamic properties, and insertion mechanisms of these species. The synthesis of chiral compounds is of critical importance in the pharmaceutical and polymer chemical industries. This project provides valuable research training for undergraduates at the University of Chicago, Lake Forest College, and other Chicago-area undergraduate schools. The project also offers exciting science experiences for high school students from the Chicago Public School system through the University of Chicago Collegiate Scholars Program.

无机、生物无机和有机金属化学项目支持芝加哥大学Richard F. Jordan教授的研究，以设计合成对映纯4族茂金属的一般方法和用于不对称催化的新催化剂库。新的手性茂金属使得新的催化、立体选择性的C-H功能化反应得以发展，这些反应可用于有机合成和合成主链上含有杂环的新型聚合物。对烯烃和炔配合物的研究为这些物质的结构、热力学、动力学、动力学性质和插入机理提供了新的认识。手性化合物的合成在制药和高分子化学工业中具有至关重要的意义。该项目为芝加哥大学、森林湖学院和其他芝加哥地区本科院校的本科生提供了宝贵的研究培训。该项目还通过芝加哥大学学者计划为芝加哥公立学校系统的高中生提供令人兴奋的科学体验。