CRIF:MU - Acquisition of a Q-TOF Mass Spectrometer for Departmental Research and Education in Chemistry

凭借化学研究仪器和设施：多用户（CRIF：MU）计划的这一奖项，来自芝加哥大学的Richard Jordan教授及其同事Chuan He，Gregory Hillhouse，Rustem Ismagilov和Hisashi Yamamoto将获得一台与液相色谱仪耦合的四极杆飞行时间（Q-TOF）质谱仪。该提案将加强各级的研究培训和教育，特别是在以下研究领域：（a）第4族金属茂催化剂的合成、反应性和机理，（B）低配位镍的基团转移反应，（c）用于催化有机转化的金属芳基氧化物，（d）过渡金属介导的碳-碳键和通过有机合成中的C-H活化形成C-杂原子键，（e）神经胶质-神经元网络的化学方法，和（f）控制细胞-材料界面的模块组件。这将液相色谱的物理分离能力与质谱的质量分析能力相结合。液相色谱仪把混合物分离成分子组分。这些成分流入质谱仪，在那里测量它们的质量及其碎片的质量。Q-TOF质谱仪是一种特殊的设计，可提供高质量精度，灵敏度和分辨率，允许检测和确定复杂混合物中分子的结构。这些仪器不仅将用于研究，而且还将用于实验室课程，以培训大量学生使用这一重要的分析技术，并与芝加哥公立高中和附近的大学，如芝加哥州立大学、州长州立大学、东北伊利诺伊大学和罗斯福大学开展外联活动。

With this award from the Chemistry Research Instrumentation and Facilities: Multi-user (CRIF:MU) program, Professor Richard Jordan and colleagues Chuan He, Gregory Hillhouse, Rustem Ismagilov and Hisashi Yamamoto from the University of Chicago will acquire a quadrupole-time-of-flight (Q-TOF) mass spectrometer coupled to a liquid chromatograph. The proposal will enhance research training and education at all levels, especially in areas of study such as (a) synthesis, reactivity and mechanisms of Group 4 metallocene catalysts, (b) group transfer reactions of low-coordinate nickel, (c) metal aryl oxides for catalytic organic transformations, (d) transition metal mediated carbon-carbon bond and C-heteroatom bond formation via C-H activation in organic synthesis, (e) chemical approaches to glial-neuronal networks, and (f) modular assemblies for controlling the cell-material interfaces.This mass spectrometer (Q-TOF) will be coupled to a high-resolution liquid chromatography system. This combines the physical separation capability of liquid chromatography with the mass analysis ability of mass spectrometry. The liquid chromatograph separates a mixture into its molecular components. These components flow into a mass spectrometer where their masses, and those of their fragments, are measured. A Q-TOF mass spectrometer is a special design that provides high mass accuracy, sensitivity and resolution that allows detection and determination of the structure of molecules in a complex mixture. The instrumentation will be used not only for research but also in laboratory courses to train significant numbers of students in the use of this important analytical technique and for outreach activities with Chicago public high schools and nearby universities such as Chicago State University, Governors State University, Northeastern Illinois University and Roosevelt University.