Synthetic Analogues of Methanobactin

甲烷菌素的合成类似物

• 批准号: 0911407
• 负责人: Daniel Rabinovich
• 金额: $ 32.5万
• 依托单位: University of North Carolina at Charlotte
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0911407&HistoricalAwards=false
• 关键词: Synthetic; Analogues; Methanobactin

The thrust of this project is the preparation of a series of synthetic analogues of methanobactin, a small copper-containing protein that is present in methane-oxidizing bacteria and exhibits potent bacteriostatic activity. Several new families of copper(I) complexes containing chelating bis(thione) and bis(selone) ligands will be synthesized with the goal of understanding the influence of the coordination environment on the high affinity that methanobactin exhibits for extracellular copper. In addition, the potential antibacterial activity of these compounds against S. aureus will be explored. The project is interdisciplinary in nature, ranging from synthetic inorganic chemistry to microbiology, and will attract students with a diversity of backgrounds and interests.With this award, the Inorganic, Bioinorganic and Organometallic (IBO) program is supporting the research of Professor Daniel Rabinovich of the Department of Chemistry at the University of North Carolina at Charlotte. Professor Rabinovich?s research efforts in synthetic and structural inorganic and organometallic chemistry center on the application of a variety of sulfur-donor ligands to the preparation of synthetic analogues of a variety of sulfur-rich metallobiomolecules that are biologically active or mimic catalytic industrial processes such as hydrogen generation.

该项目的重点是制备一系列甲烷杆菌素的合成类似物，甲烷杆菌素是一种小型含铜蛋白质，存在于甲烷氧化细菌中，具有有效的抑菌活性。 将合成含有螯合双（硫酮）和双（硒酮）配体的几个新的铜（I）配合物家族，目的是了解配位环境对甲烷菌素对细胞外铜表现出的高亲和力的影响。 此外，还将探讨这些化合物对金黄色葡萄球菌的潜在抗菌活性。 该项目本质上是跨学科的，从合成无机化学到微生物学，将吸引具有不同背景和兴趣的学生。通过该奖项，无机、生物无机和有机金属（IBO）项目将支持北卡罗来纳大学夏洛特分校化学系 Daniel Rabinovich 教授的研究。 Rabinovich 教授在合成和结构无机和有机金属化学方面的研究工作集中在应用各种硫供体配体制备各种富硫金属生物分子的合成类似物，这些分子具有生物活性或模拟催化工业过程，例如制氢。