Syntheses and properties of near-IR BODIPY-based fluorophores

基于近红外 BODIPY 的荧光团的合成和性质

• 批准号: 0911629
• 负责人: Maria Vicente
• 金额: $ 49万
• 依托单位: Louisiana State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2013-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0911629&HistoricalAwards=false
• 关键词: Syntheses; properties; near; IR; BODIPY

"This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5)".This project aims to synthesize and evaluate a new series of fluorescent dyes for potential applications in bioimaging, in bioanalyses or in medicine. These new materials offer a number of unique opportunities compared with currently available dyes; they can be synthesized from commercially available compounds in a small number of steps, can be rendered water-soluble, and will have very high fluorescence quantum efficiencies and photochemical stabilities. Following the total synthesis, the new materials will be purified, and their chemical and photophysical properties will be studied. The most promising dyes will be conjugated with a biomolecule, such as a peptide, protein or antibody, and their potential for application in bioimaging, bioanalyses or medicine will be investigated. This multi-disciplinary project will likely lead to the discovery of new fluorescent dyes for applications as biomarkers or as anti-cancer drugs and will have broad impacts in the fields of organic and bioconjugate chemistry, cell and molecular biology, proteomics, biomedical imaging, fluorescence-based detection technologies, drug discovery, and clinical medicine.The principal investigator, Dr. Vicente, is a minority Latino/Hispanic professor and currently the only woman full professor in the Department of Chemistry at Louisiana State University. Dr. Vicente has a strong track record of participation in multi-disciplinary projects and is highly committed to broaden the participation of woman and minority students in research at LSU. She is currently leading the Initiative for Maximizing Student Diversity Program at LSU, which provides to qualified undergraduates from under-represented groups interdisciplinary research training while enhancing diversity in chemistry and the basic sciences. Dr. Vicente and her students will participate in several high impact education and outreach programs already established at LSU, and will develop demonstrations based on basic scientific concepts, such as interactions of light with matter and color, for outreach to Louisiana schools that will be incorporated into already established service learning activities at LSU.

“该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的”。该项目旨在合成和评估一系列新的荧光染料，用于生物成像，生物分析或医学的潜在应用。与目前可用的染料相比，这些新材料提供了许多独特的机会;它们可以通过少量步骤从市售化合物合成，可以使其溶于水，并且具有非常高的荧光量子效率和光化学稳定性。在全合成之后，将对新材料进行纯化，并研究其化学和物理性质。最有前途的染料将与生物分子，如肽，蛋白质或抗体缀合，并将研究它们在生物成像，生物分析或医学中的应用潜力。这个多学科的项目可能会导致发现新的荧光染料作为生物标志物或抗癌药物的应用，并将在有机和生物共轭化学，细胞和分子生物学，蛋白质组学，生物医学成像，荧光检测技术，药物发现和临床医学领域产生广泛的影响。首席研究员，博士.她是一位少数族裔的拉丁裔/西班牙裔教授，目前是路易斯安那州立大学化学系唯一的女教授。文森特在多学科项目的参与有着良好的记录，并高度致力于扩大妇女和少数民族学生在路易斯安那州立大学的研究参与。她目前正在领导LSU最大化学生多样性计划的倡议，该计划为来自代表性不足的群体的合格本科生提供跨学科研究培训，同时提高化学和基础科学的多样性。文森特和她的学生将参加几个高影响力的教育和推广计划已经在路易斯安那州立大学建立，并将开发基于基本科学概念的演示，如光与物质和颜色的相互作用，外展到路易斯安那州的学校，将被纳入已经建立的服务学习活动在路易斯安那州立大学。