Ross River virus - identification of virulence determinants in clinical isolates from across Australia

在澳大利亚，罗斯河病毒（RRV）是影响人类健康的最常见虫媒病毒。在1993年至2008年期间，有超过60，000例RRV确诊病例。这种疾病虽然不致命，但发病率很高，给个人、家庭和社区带来社会和经济代价。该项目有几个国家利益。它将阐明RRV毒株与人类疾病严重程度之间是否存在任何联系。它还将确定病毒标志物，这些标志物可以帮助公共卫生官员确定爆发的可能疾病结果，并可以为设计抗病毒策略提供新的途径。

In Australia, Ross River virus (RRV) is the most common insect borne virus that affects human health. There were more than 60,000 confirmed cases of RRV between 1993 and 2008. While not fatal, the disease is responsible for significant morbidity that has both social and economic costs for the individual, their family and the community. The project has several national benefits. It will elucidate whether there is any association between RRV strain and the severity of human disease. It will also identify viral markers that could assist public health officials in determining likely disease outcomes of outbreaks and could provide new avenues for the design of antiviral strategies.