Inhibition of interferon-?/? induction by Ross River virus

抑制干扰素-?/?

• 批准号: nhmrc : 1031024
• 负责人: Prof Suresh Mahalingam
• 金额: $ 39.32万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/inhibition-interferon-induction-river-virus/110783
• 关键词: Inhibition; interferon; induction; Ross; River

Ross River virus is a mosquito-borne virus that causes arthritis in the joints of many people infected. This project will look at the early interactions of a virulent virus with the mammalian host that appear to enable the virus to replicate and spread in the host and thereby cause disease. These interactions are with the host interferon protein which the virus has developed the ability to inhibit. The effect of the invading virus on the host's interferon system, part of the immune system, will be examined.

罗斯河病毒是一种由蚊子传播的病毒，会导致许多感染者的关节出现关节炎。该项目将研究剧毒病毒与哺乳动物宿主的早期相互作用，这种相互作用似乎使病毒能够在宿主体内复制和传播，从而引起疾病。这些相互作用是与宿主干扰素蛋白的相互作用，病毒已经具备了抑制干扰素蛋白的能力。将检查入侵病毒对宿主干扰素系统（免疫系统的一部分）的影响。