The biology of arbovirus virulence and fitness in arthropod and vertebrate hosts in vivo

节肢动物和脊椎动物宿主体内虫媒病毒毒力和适应性的生物学

• 批准号: DP0774082
• 负责人: Prof Suresh Mahalingam
• 金额: $ 21.85万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-09-21 至 2010-09-21
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0774082
• 关键词: biology; arbovirus; virulence; fitness; arthropod

In Australia, Ross River virus (RRV) represents significant concern to human health. Between 1992-2005 more than 50,000 notifications of RRV infection have been reported. While not fatal, the disease is responsible for morbidity in the community/individual that can have both social and economic costs. The project has several national benefits. It will help elucidate whether there is any association between RRV strain and increased risk of RRV transmission and/or occurrence of more severe cases of human disease. It will help develop technologies that can lead towards the identification of viral markers, which could provide new avenues in the design of novel antiviral strategies.

在澳大利亚，罗斯河病毒（RRV）对人类健康造成了严重影响。在1992-2005年期间，报告了50 000多份RRV感染的报告。虽然不致命，但这种疾病是社区/个人发病的原因，可能造成社会和经济代价。该项目有几个国家利益。这将有助于阐明RRV毒株与RRV传播风险增加和/或发生更严重的人类疾病病例之间是否存在任何关联。它将有助于开发能够识别病毒标志物的技术，这可能为设计新的抗病毒策略提供新的途径。