The biology of arbovirus virulence and fitness in arthropod and vertebrate hosts in vivo

在澳大利亚，罗斯河病毒(RRV)是对人类健康的重大关切。1992-2005年间，报告了50,000多起轮状病毒感染的报告。虽然这种疾病不是致命的，但它导致了社区/个人的发病率，这可能会造成社会和经济代价。该项目有几个全国性的好处。这将有助于阐明RRV株与RRV传播风险增加和/或发生更严重的人类疾病之间是否存在任何联系。它将有助于开发能够识别病毒标志物的技术，这可能为设计新的抗病毒策略提供新的途径。

In Australia, Ross River virus (RRV) represents significant concern to human health. Between 1992-2005 more than 50,000 notifications of RRV infection have been reported. While not fatal, the disease is responsible for morbidity in the community/individual that can have both social and economic costs. The project has several national benefits. It will help elucidate whether there is any association between RRV strain and increased risk of RRV transmission and/or occurrence of more severe cases of human disease. It will help develop technologies that can lead towards the identification of viral markers, which could provide new avenues in the design of novel antiviral strategies.