MRI: Acquisition of a Remotely Accessible 400 MHz Spectrometer

MRI：获取可远程访问的 400 MHz 光谱仪

• 批准号: 0922623
• 负责人: Jeffrey Johnson
• 金额: $ 41.68万
• 依托单位: Hope College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0922623&HistoricalAwards=false
• 关键词: MRI; Acquisition; Remotely; Accessible; 400

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).With this award from the Major Research Instrumentation (MRI) program, Jeffrey B. Johnson and colleague Moses Lee from Hope College will acquire a 400 MHz NMR spectrometer to support research that includes mechanistic elucidation of transition metal-catalyzed carbon-carbon bond activation methodology, design of prodrugs for possible applications in prostate cancer, synthesis and analysis of organic photochromes, polymer synthesis and characterization for use in light emitting electrochemical cells (LEC), and assessment of phosphates in lake sediments. The spectrometer will also provide research opportunities at collaborating community colleges through cyber infrastructure.Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic/inorganic chemistry, biochemistry, environmental and energy research. This instrument will be an integral part of teaching as well as research.

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助。与此从主要研究仪器（MRI）计划，杰弗里B奖。来自霍普学院的约翰逊和同事摩西·李将获得一台400 MHz核磁共振光谱仪，以支持研究，包括过渡金属催化的碳-碳键活化方法的机理阐明、可能应用于前列腺癌的前药设计、有机光致变色剂的合成和分析、用于发光电化学电池（LEC）的聚合物合成和表征、以及湖泊沉积物中磷酸盐的评估。该光谱仪还将通过网络基础设施为合作的社区学院提供研究机会。核磁共振（NMR）光谱是化学家用于阐明分子结构的最强大工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。这些NMR研究的结果将对合成有机/无机化学、生物化学、环境和能源研究产生影响。该仪器将成为教学和研究的一个组成部分。

项目成果

Pyridine-directed carbon–carbon single bond activation: Rhodium-catalyzed decarbonylation of aryl and heteroaromatic ketones

吡啶引导的碳-碳单键活化：铑催化芳基和杂芳酮的脱羰

• DOI: 10.1016/j.tetlet.2021.153132
• 发表时间: 2021
• 期刊: Tetrahedron Letters
• 影响因子: 1.8
• 作者: Wagner, Cole J.;Salisbury, Eric A.;Schoonover, Erik J.;VanderRoest, Jacob P.;Johnson, Jeffrey B.
• 通讯作者: Johnson, Jeffrey B.