RUI: Carbon-carbon single bond activation as a route to new organic transformations
RUI:碳-碳单键活化作为新有机转化的途径
基本信息
- 批准号:1764118
- 负责人:
- 金额:$ 27.39万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-09-01 至 2022-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
In this project funded by the Chemical Catalysis Program of the Chemistry Division, Professor Jeffrey B. Johnson of the Department of Chemistry at Hope College is developing new methods for the efficient production of organic compounds through the activation of carbon-carbon bonds. Carbon-carbon bonds are extremely common, making up the framework of molecules derived from living things as well as many polymers and other important materials. Despite their prevalence, there are few reaction conditions known that can selectively break these bonds. Professor Johnson and his group of undergraduate collaborators are working to understand the processes by which these few known reactions occur. They are using this information to develop new methods to activate and transform carbon-carbon bonds. Successful realization of these goals promises more efficient synthetic routes to complex molecules, including new compounds that can be examined for biological activity as potential pharmaceutical agents. Undergraduate students strengthen their personal scientific preparation through participation in this project. In turn, these undergraduates serve as Upward Bound mentors, assisting at-risk high school students prepare for college and potential futures in STEM fields. Professor Jeffrey B. Johnson is developing new reactions for the transition metal-catalyzed activation and functionalization of carbon-carbon single bonds. Undergraduate collaborators are carrying out the mechanistic investigation of the rhodium-catalyzed decarbonylation of 2-pyridylbenzophenones, determining energy barriers and identifying reaction intermediates. As Lewis basic directing groups are generally required for selective carbon-carbon bond activation, efforts focus on the use of readily removed or manipulated directing groups for the identification of conditions that allow the use of a broad range of ketones and carboxylic acid derivatives. The activation of these substrates, followed by coupling with readily available pi systems or organometallics, promises rapid access to a wide range of complex molecules with potential biological activity.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
在这个由化学系化学催化计划资助的项目中,霍普学院化学系的杰弗里·B·约翰逊教授正在开发通过激活碳-碳键高效生产有机化合物的新方法。碳-碳键是非常常见的,它构成了来自生物的分子以及许多聚合物和其他重要材料的框架。尽管它们普遍存在,但几乎没有已知的反应条件可以选择性地打破这些键。约翰逊教授和他的本科生合作者团队正在努力了解这些鲜为人知的反应发生的过程。他们正在利用这些信息开发新的方法来激活和转化碳-碳键。这些目标的成功实现保证了获得复杂分子的更有效的合成路线,包括可以作为潜在药剂检查生物活性的新化合物。本科生通过参与该项目加强个人的科学准备。反过来,这些本科生充当向上的导师,帮助高危高中生为大学和STEM领域的潜在未来做准备。杰弗里·B·约翰逊教授正在为过渡金属催化的碳-碳单键的活化和功能化开发新的反应。本科生的合作者正在开展2-吡啶基二苯甲酮在铑催化下的脱羰反应的机理研究,确定能垒并确定反应中间体。由于选择性碳-碳键活化通常需要Lewis碱性导向基团,因此努力集中于使用容易移除或操纵的导向基团,以确定允许使用广泛范围的酮和羧酸衍生物的条件。激活这些底物,然后与现成的PI系统或有机金属相结合,有望快速获得具有潜在生物活性的广泛复杂分子。该奖项反映了NSF的法定使命,并通过使用基金会的智力优势和更广泛的影响审查标准进行评估,被认为值得支持。
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Pyridine-directed carbon–carbon single bond activation: Rhodium-catalyzed decarbonylation of aryl and heteroaromatic ketones
吡啶引导的碳-碳单键活化:铑催化芳基和杂芳酮的脱羰
- DOI:10.1016/j.tetlet.2021.153132
- 发表时间:2021
- 期刊:
- 影响因子:1.8
- 作者:Wagner, Cole J.;Salisbury, Eric A.;Schoonover, Erik J.;VanderRoest, Jacob P.;Johnson, Jeffrey B.
- 通讯作者:Johnson, Jeffrey B.
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Jeffrey Johnson其他文献
Expert Q-Analysis
- DOI:
10.1068/b170221 - 发表时间:
1990-06 - 期刊:
- 影响因子:0
- 作者:
Jeffrey Johnson - 通讯作者:
Jeffrey Johnson
Visual communication in swarms of intelligent robot agents
- DOI:
10.1007/bf02481313 - 发表时间:
2001-03-01 - 期刊:
- 影响因子:0.800
- 作者:
Jeffrey Johnson - 通讯作者:
Jeffrey Johnson
33 Thrombopoietin in pre-eclampsia and HELLP syndrome
- DOI:
10.1016/s0002-9378(01)80068-5 - 发表时间:
2001-12-01 - 期刊:
- 影响因子:
- 作者:
Jeffrey Johnson;Douglas Kniss;Philip Samuels - 通讯作者:
Philip Samuels
Recommendations on TANF Reauthorization from the Strengthening Fragile Families Initiative Statement before the U.S. House of Representatives Ways and Means Committee, Subcommittee on Human Resources
美国众议院筹款委员会人力资源小组委员会提交的《加强脆弱家庭倡议声明》关于重新授权贫困家庭临时援助 (TANF) 的建议
- DOI:
- 发表时间:
2002 - 期刊:
- 影响因子:0
- 作者:
E. Sorensen;Dwaine R. Simms;R. Mincy;Joseph T. Jones;Jeffrey Johnson;Preston J Garrison;I. Garfinkel - 通讯作者:
I. Garfinkel
Q-ANALYSIS OF ROAD INTERSECTIONS
- DOI:
10.1016/s0020-7373(76)80019-3 - 发表时间:
1976-09 - 期刊:
- 影响因子:0
- 作者:
Jeffrey Johnson - 通讯作者:
Jeffrey Johnson
Jeffrey Johnson的其他文献
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{{ truncateString('Jeffrey Johnson', 18)}}的其他基金
SBIR Phase II: Autonomous active safety systems for verifiably safe operation of ground vehicles
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- 批准号:
2240322 - 财政年份:2023
- 资助金额:
$ 27.39万 - 项目类别:
Cooperative Agreement
Stereoselective Reactions of Aromatic Building Blocks
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2246693 - 财政年份:2023
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$ 27.39万 - 项目类别:
Standard Grant
Doctoral Dissertation Research: Social network position and causes of fatigue within participatory water governance networks
博士论文研究:参与式水治理网络中的社会网络地位和疲劳原因
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2214135 - 财政年份:2022
- 资助金额:
$ 27.39万 - 项目类别:
Standard Grant
Doctoral Dissertation Research: Cognitive processes underlying variation in human-environment interactions
博士论文研究:人类与环境相互作用变化背后的认知过程
- 批准号:
2048655 - 财政年份:2021
- 资助金额:
$ 27.39万 - 项目类别:
Standard Grant
SBIR Phase I: Autonomous active safety systems for verifiably safe operation of ground vehicles
SBIR 第一阶段:用于地面车辆可验证安全运行的自主主动安全系统
- 批准号:
2006225 - 财政年份:2020
- 资助金额:
$ 27.39万 - 项目类别:
Standard Grant
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CAS:原料化学品产生的复杂反应
- 批准号:
1954835 - 财政年份:2020
- 资助金额:
$ 27.39万 - 项目类别:
Standard Grant
RAPID Collaborative: Networks and Spatial Dynamics of the US Food Supply Chain amid the COVID-19 Pandemic
RAPID 协作:COVID-19 大流行期间美国食品供应链的网络和空间动态
- 批准号:
2032312 - 财政年份:2020
- 资助金额:
$ 27.39万 - 项目类别:
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合作研究:拉哈尔动力学和监测:基于次声的多参数方法
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1914491 - 财政年份:2019
- 资助金额:
$ 27.39万 - 项目类别:
Standard Grant
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火山声源:从次声信号中解耦火山口调制
- 批准号:
1830976 - 财政年份:2019
- 资助金额:
$ 27.39万 - 项目类别:
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- 批准号:
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- 资助金额:
$ 27.39万 - 项目类别:
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