MRI: Upgrade of a 600 MHz Spectrometer for high-sensitivity Nuclear Magnetic Resonance (NMR)

MRI：升级 600 MHz 光谱仪，用于高灵敏度核磁共振 (NMR)

• 批准号: 1828183
• 负责人: Jeffrey Johnson
• 金额: $ 44.48万
• 依托单位: University of North Carolina at Chapel Hill
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-10-01 至 2021-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1828183&HistoricalAwards=false
• 关键词: MRI; Upgrade; 600; MHz; Spectrometer

This award is supported by the Major Research Instrumentation, and the Chemistry Research Instrumentation programs. Professor Jeffrey Johnson from University of North Carolina at Chapel Hill and colleagues Gary Pielak, Alexander Miller, Jillian Dempsey and Bo Li have upgraded the console of a 600 MHz NMR spectrometer and have equipped the spectrometer with a cryoplatform to allow higher sensitivity. This will transform and old instrument into a modern spectrometer. This upgraded spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as allow study of biologically relevant species. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The cryogenic probe provides a significant increase in sensitivity relative to standard NMR probes which permits use of small samples. The instrument is used for research and research training at this university and neighboring schools. The proposal is aimed at enhancing research and education at all levels. It especially impacts studies of complexity-building reactions from feedstock chemicals as well as utilization of proton-coupled electron transfer in solar fuel production. The spectrometer is used to investigate quantum dots and in the exploration of structural and functional diversity of microbial natural products and in the identification of new microbial natural products. The upgraded instrument is also employed in characterizing biosynthetic intermediates in natural product pathways and for probing mechanisms in sustainable organometallic catalysis. Fluorine NMR in cells is used to probe globular proteins.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项得到了主要的研究工具和化学研究工具计划的支持。来自北卡罗来纳大学教堂山大学的杰弗里·约翰逊（Jeffrey Johnson）教授，同事加里·皮拉克（Gary Pielak），亚历山大·米勒（Alexander Miller），吉利安·登普西（Jillian Dempsey）和博·李（Bo Li）升级了600 MHz NMR光谱仪的控制台，并为光谱仪配备了频谱仪，以允许更高的敏感性。这将转换为现代光谱仪。该升级的光谱仪允许在各种领域进行研究，例如加速具有重要经济意义的化学反应的领域，并允许研究生物学相关的物种。通常，核磁共振（NMR）光谱是化学家可用于阐明分子结构的最强大工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子或固态中分子之间相互作用的动力学。对于正在进行边境研究的化学家来说，获得最先进的NMR光谱仪至关重要。低温探针相对于标准NMR探针的灵敏度显着提高，该探针允许使用小样品。该仪器用于该大学和邻近学校的研究和研究培训。该提案旨在增强各级研究和教育。它特别影响了对原料化学物质的复杂性建筑反应的研究，以及在太阳能燃料生产中对质子耦合电子转移的利用。光谱仪用于研究量子点以及探索微生物天然产物的结构和功能多样性以及鉴定新的微生物天然产物。升级的仪器还用于表征天然产物途径中的生物合成中间体以及可持续有机金属催化中的探测机制。细胞中的氟NMR用于探测球状蛋白。该奖项反映了NSF的法定任务，并使用基金会的知识分子优点和更广泛的影响审查标准，被认为值得通过评估来支持。

项目成果

De Novo Synthesis of the DEF-Ring Stereotriad Core of the Veratrum Alkaloids

• DOI: 10.1021/acs.joc.0c00685
• 发表时间: 2020-05-15
• 期刊: JOURNAL OF ORGANIC CHEMISTRY
• 影响因子: 3.6
• 作者: Horwitz, Matthew A.;Robins, Jacob G.;Johnson, Jeffrey S.
• 通讯作者: Johnson, Jeffrey S.

Revealing the Molecular Identity of Defect Sites on PbS Quantum Dot Surfaces with Redox-Active Chemical Probes

• DOI: 10.1021/acs.chemmater.1c00520
• 发表时间: 2021-03-16
• 期刊: CHEMISTRY OF MATERIALS
• 影响因子: 8.6
• 作者: Hartley, Carolyn L.;Dempsey, Jillian L.
• 通讯作者: Dempsey, Jillian L.

Progress toward a Convergent, Asymmetric Synthesis of Jervine

Jervine 的收敛、不对称合成取得进展

• DOI: 10.1021/acs.orglett.0c00972
• 发表时间: 2020
• 期刊: Organic Letters
• 影响因子: 5.2
• 作者: Zavesky, Blane P.;De Jesús Cruz, Pedro;Johnson, Jeffrey S.
• 通讯作者: Johnson, Jeffrey S.

A bis(arylphosphinito)amide pincer ligand that binds nickel forming six-membered metallacycles

一种双（芳基亚膦基）酰胺钳配体，可结合镍形成六元金属环

• DOI: 10.1016/j.poly.2020.114380
• 发表时间: 2020
• 期刊: Polyhedron
• 影响因子: 2.6
• 作者: Bruch, Quinton J.;Miller, Alexander J.M.
• 通讯作者: Miller, Alexander J.M.

Stepwise Iodide-Free Methanol Carbonylation via Methyl Acetate Activation by Pincer Iridium Complexes

通过钳铱络合物活化乙酸甲酯进行逐步无碘化物甲醇羰基化

• DOI: 10.1021/jacs.1c05185
• 发表时间: 2021
• 期刊: Journal of the American Chemical Society
• 影响因子: 15
• 作者: Yoo, Changho;Miller, Alexander J.
• 通讯作者: Miller, Alexander J.