MRI: Upgrade of a 600 MHz Spectrometer for high-sensitivity Nuclear Magnetic Resonance (NMR)

该奖项由主要研究仪器项目和化学研究仪器项目支持。北卡罗来纳大学教堂山分校的Jeffrey Johnson教授及其同事Gary Pielak、Alexander Miller、Jillian Dempsey和Bo Li升级了600 MHz核磁共振光谱仪的控制台，并为光谱仪配备了冷冻平台，以实现更高的灵敏度。这将把旧仪器改造成现代光谱仪.这种升级的光谱仪允许在各种领域进行研究，例如那些加速具有重大经济意义的化学反应的领域，以及允许研究生物相关物种。总的来说，核磁共振波谱是化学家用来阐明分子结构的最强大的工具之一。它被用来识别未知物质，表征分子中原子的特定排列，并研究分子在溶液或固体中相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。与允许使用小样本的标准核磁共振探头相比，低温探头的灵敏度显著提高。该仪器用于这所大学和邻近学校的研究和研究性培训。该提案旨在加强各级的研究和教育。它尤其影响从原料化学品中建立复杂反应以及在太阳能燃料生产中利用质子耦合电子转移的研究。光谱仪用于研究量子点，探索微生物天然产物的结构和功能多样性，并用于鉴定新的微生物天然产物。升级后的仪器还用于表征天然产物途径中的生物合成中间体，并用于探索可持续有机金属催化的机理。细胞中的氟核磁共振用于探测球状蛋白。这一奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

This award is supported by the Major Research Instrumentation, and the Chemistry Research Instrumentation programs. Professor Jeffrey Johnson from University of North Carolina at Chapel Hill and colleagues Gary Pielak, Alexander Miller, Jillian Dempsey and Bo Li have upgraded the console of a 600 MHz NMR spectrometer and have equipped the spectrometer with a cryoplatform to allow higher sensitivity. This will transform and old instrument into a modern spectrometer. This upgraded spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as allow study of biologically relevant species. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The cryogenic probe provides a significant increase in sensitivity relative to standard NMR probes which permits use of small samples. The instrument is used for research and research training at this university and neighboring schools. The proposal is aimed at enhancing research and education at all levels. It especially impacts studies of complexity-building reactions from feedstock chemicals as well as utilization of proton-coupled electron transfer in solar fuel production. The spectrometer is used to investigate quantum dots and in the exploration of structural and functional diversity of microbial natural products and in the identification of new microbial natural products. The upgraded instrument is also employed in characterizing biosynthetic intermediates in natural product pathways and for probing mechanisms in sustainable organometallic catalysis. Fluorine NMR in cells is used to probe globular proteins.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.