CAS: Complexity-Building Reactions from Feedstock Chemicals
CAS:原料化学品产生的复杂反应
基本信息
- 批准号:1954835
- 负责人:
- 金额:$ 45万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-08-01 至 2023-07-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
With this award, the Chemical Synthesis Program of the NSF Division of Chemistry is supporting the research of Professor Jeffrey S. Johnson of the Department of Chemistry at the University of North Carolina at Chapel Hill. Professor Johnson and his research team are creating new chemical processes that provide high-value molecules from abundant feedstock chemicals (even “waste” chemicals). Sustainability is a critical challenge facing society and the field of chemistry. The focus on using abundant chemicals to access complex molecules through the creative use of catalytic processes is addressing the societal need for new pharmaceuticals and materials with sustainable sources. These studies are being paired with efforts by Professor Johnson and his research group to enhance public outreach in STEM (science, technology, engineering, and mathematics) and to support the inclusion of students from underrepresented groups in chemistry. The Johnson group has a notable track record in successfully mentoring diverse students through the doctoral program and on to leadership positions.High abundance and inexpensive starting materials such as carbon dioxide, carbon monoxide, ammonia, and aromatic compounds are often viewed as ‘dead-end’ molecules because of their stability and relative inertness. Professor Johnson and his research group are developing new reactions that will take these abundant, poorly-reactive molecules and convert them into useful synthetic building blocks. The Johnson research team is transforming achiral aromatic compounds into chiral carbocycles through catalyzed dearomatization reactions that result in cyclohexadienoid systems bearing strained fused rings, such as norcaradienes. These systems can then be used to incorporate feedstock compounds of the sort described. In this way, the Johnson group is pursuing the streamlined and stereoselective assemblies of useful advanced chiral and densely functionalized heterocyclic structures while incorporating abundant inexpensive gaseous feedstock at the same time. These activities provide an excellent training ground in synthetic chemistry for a diverse group of graduate and undergraduate students.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
有了这个奖项,美国国家科学基金会化学部的化学合成计划正在支持杰弗里·S。查佩尔山的北卡罗来纳州大学化学系的约翰逊说。约翰逊教授和他的研究团队正在创造新的化学工艺,从丰富的原料化学品(甚至是“废物”化学品)中提供高价值的分子。可持续性是社会和化学领域面临的一个关键挑战。通过创造性地使用催化过程,使用丰富的化学品来获得复杂分子的重点是解决社会对具有可持续来源的新药物和材料的需求。这些研究与约翰逊教授及其研究小组的努力相结合,以加强STEM(科学,技术,工程和数学)的公众宣传,并支持将来自代表性不足的群体的学生纳入化学。约翰逊团队在成功指导不同学生完成博士课程并担任领导职位方面有着显著的记录。高丰度和廉价的起始材料,如二氧化碳,一氧化碳,氨和芳香族化合物,由于其稳定性和相对惰性,通常被视为“死胡同”分子。约翰逊教授和他的研究小组正在开发新的反应,将这些丰富的,反应性差的分子转化为有用的合成积木。约翰逊研究小组正在通过催化脱芳构化反应将非手性芳族化合物转化为手性碳环,该反应导致带有应变稠环的环己二烯体系,如降碳二烯。 然后,这些系统可用于掺入所述种类的原料化合物。通过这种方式,约翰逊集团正在追求有用的先进手性和密集官能化的杂环结构的流线型和立体选择性组装,同时引入丰富的廉价气态原料。 该奖项反映了NSF的法定使命,并通过使用基金会的智力价值和更广泛的影响审查标准进行评估,被认为值得支持。
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Dearomative Synthesis of Chiral Dienes Enables Improved Late-Stage Ligand Diversification
- DOI:10.1021/acs.orglett.2c00183
- 发表时间:2022-03-11
- 期刊:
- 影响因子:5.2
- 作者:Crawford, Evan T.;Smith, Kendrick L.;Johnson, Jeffrey S.
- 通讯作者:Johnson, Jeffrey S.
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Jeffrey Johnson其他文献
Expert Q-Analysis
- DOI:
10.1068/b170221 - 发表时间:
1990-06 - 期刊:
- 影响因子:0
- 作者:
Jeffrey Johnson - 通讯作者:
Jeffrey Johnson
Visual communication in swarms of intelligent robot agents
- DOI:
10.1007/bf02481313 - 发表时间:
2001-03-01 - 期刊:
- 影响因子:0.800
- 作者:
Jeffrey Johnson - 通讯作者:
Jeffrey Johnson
33 Thrombopoietin in pre-eclampsia and HELLP syndrome
- DOI:
10.1016/s0002-9378(01)80068-5 - 发表时间:
2001-12-01 - 期刊:
- 影响因子:
- 作者:
Jeffrey Johnson;Douglas Kniss;Philip Samuels - 通讯作者:
Philip Samuels
Recommendations on TANF Reauthorization from the Strengthening Fragile Families Initiative Statement before the U.S. House of Representatives Ways and Means Committee, Subcommittee on Human Resources
美国众议院筹款委员会人力资源小组委员会提交的《加强脆弱家庭倡议声明》关于重新授权贫困家庭临时援助 (TANF) 的建议
- DOI:
- 发表时间:
2002 - 期刊:
- 影响因子:0
- 作者:
E. Sorensen;Dwaine R. Simms;R. Mincy;Joseph T. Jones;Jeffrey Johnson;Preston J Garrison;I. Garfinkel - 通讯作者:
I. Garfinkel
Q-ANALYSIS OF ROAD INTERSECTIONS
- DOI:
10.1016/s0020-7373(76)80019-3 - 发表时间:
1976-09 - 期刊:
- 影响因子:0
- 作者:
Jeffrey Johnson - 通讯作者:
Jeffrey Johnson
Jeffrey Johnson的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Jeffrey Johnson', 18)}}的其他基金
SBIR Phase II: Autonomous active safety systems for verifiably safe operation of ground vehicles
SBIR 第二阶段:用于地面车辆可验证安全运行的自主主动安全系统
- 批准号:
2240322 - 财政年份:2023
- 资助金额:
$ 45万 - 项目类别:
Cooperative Agreement
Stereoselective Reactions of Aromatic Building Blocks
芳香族嵌段的立体选择性反应
- 批准号:
2246693 - 财政年份:2023
- 资助金额:
$ 45万 - 项目类别:
Standard Grant
Doctoral Dissertation Research: Social network position and causes of fatigue within participatory water governance networks
博士论文研究:参与式水治理网络中的社会网络地位和疲劳原因
- 批准号:
2214135 - 财政年份:2022
- 资助金额:
$ 45万 - 项目类别:
Standard Grant
Doctoral Dissertation Research: Cognitive processes underlying variation in human-environment interactions
博士论文研究:人类与环境相互作用变化背后的认知过程
- 批准号:
2048655 - 财政年份:2021
- 资助金额:
$ 45万 - 项目类别:
Standard Grant
SBIR Phase I: Autonomous active safety systems for verifiably safe operation of ground vehicles
SBIR 第一阶段:用于地面车辆可验证安全运行的自主主动安全系统
- 批准号:
2006225 - 财政年份:2020
- 资助金额:
$ 45万 - 项目类别:
Standard Grant
RAPID Collaborative: Networks and Spatial Dynamics of the US Food Supply Chain amid the COVID-19 Pandemic
RAPID 协作:COVID-19 大流行期间美国食品供应链的网络和空间动态
- 批准号:
2032312 - 财政年份:2020
- 资助金额:
$ 45万 - 项目类别:
Standard Grant
Collaborative Research: Lahar dynamics and Monitoring: A multiparametric approach grounded in infrasound
合作研究:拉哈尔动力学和监测:基于次声的多参数方法
- 批准号:
1914491 - 财政年份:2019
- 资助金额:
$ 45万 - 项目类别:
Standard Grant
The Volcano Acoustic Source: Decoupling Crater Modulation From Infrasound Signal
火山声源:从次声信号中解耦火山口调制
- 批准号:
1830976 - 财政年份:2019
- 资助金额:
$ 45万 - 项目类别:
Continuing Grant
MRI: Upgrade of a 600 MHz Spectrometer for high-sensitivity Nuclear Magnetic Resonance (NMR)
MRI:升级 600 MHz 光谱仪,用于高灵敏度核磁共振 (NMR)
- 批准号:
1828183 - 财政年份:2018
- 资助金额:
$ 45万 - 项目类别:
Standard Grant
RUI: Carbon-carbon single bond activation as a route to new organic transformations
RUI:碳-碳单键活化作为新有机转化的途径
- 批准号:
1764118 - 财政年份:2018
- 资助金额:
$ 45万 - 项目类别:
Standard Grant
相似海外基金
Building Molecular Complexity Through Enzyme-Enabled Synthesis
通过酶合成构建分子复杂性
- 批准号:
DE240100502 - 财政年份:2024
- 资助金额:
$ 45万 - 项目类别:
Discovery Early Career Researcher Award
22-BBSRC/NSF-BIO Building synthetic regulatory units to understand the complexity of mammalian gene expression
22-BBSRC/NSF-BIO 构建合成调控单元以了解哺乳动物基因表达的复杂性
- 批准号:
BB/Y008898/1 - 财政年份:2024
- 资助金额:
$ 45万 - 项目类别:
Research Grant
Building Tools to Create Molecular Complexity for Next Generation Drugs
构建为下一代药物创造分子复杂性的工具
- 批准号:
IM240100126 - 财政年份:2024
- 资助金额:
$ 45万 - 项目类别:
Mid-Career Industry Fellowships
Complexity-Building Approaches in Photoassisted Synthesis of Heterocycles
光辅助合成杂环的复杂性构建方法
- 批准号:
2247411 - 财政年份:2023
- 资助金额:
$ 45万 - 项目类别:
Standard Grant
UKRI/BBSRC-NSF/BIO Building synthetic regulatory units to understand the complexity of mammalian gene expression
UKRI/BBSRC-NSF/BIO 构建合成调控单元以了解哺乳动物基因表达的复杂性
- 批准号:
2321745 - 财政年份:2023
- 资助金额:
$ 45万 - 项目类别:
Standard Grant
Overcoming Violence and Building Peace in Conditions of Complexity in PNG
在巴布亚新几内亚复杂的情况下克服暴力并建设和平
- 批准号:
FT230100612 - 财政年份:2023
- 资助金额:
$ 45万 - 项目类别:
ARC Future Fellowships
Building biophysical and biochemical complexity in 3D cell and tissue constructs
在 3D 细胞和组织结构中构建生物物理和生化复杂性
- 批准号:
10701919 - 财政年份:2022
- 资助金额:
$ 45万 - 项目类别:
Building biophysical and biochemical complexity in 3D cell and tissue constructs
在 3D 细胞和组织结构中构建生物物理和生化复杂性
- 批准号:
10501793 - 财政年份:2022
- 资助金额:
$ 45万 - 项目类别:
Study on social complexity from the perspective of transport-animal introduction and monument building in the steppe zone
草原区交通动物引进与纪念碑建设视角下的社会复杂性研究
- 批准号:
22H00012 - 财政年份:2022
- 资助金额:
$ 45万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Complexity-building Approaches in Photoassisted Synthesis of Heterocycles
光辅助合成杂环的复杂性构建方法
- 批准号:
1955892 - 财政年份:2020
- 资助金额:
$ 45万 - 项目类别:
Standard Grant