MRI: Acquisition of a Confocal Microscope for Multi-disciplinary Research and Teaching in the Central Michigan University Multi-user Microscopy Facility

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。中密歇根大学生物系显微镜设施将获得激光扫描共聚焦显微镜，该奖项来自主要研究仪器计划。 新仪器将具有更高的灵敏度，分辨率和扫描速度，使校园内更多和更多样化的研究人员能够进行共定位研究和增强荧光标记样品的三维重建。 其研究将受益于新仪器的用户包括10名教师和他们的学生，他们在发育生物学，细胞生物学，分子遗传学，神经科学和植物生物学领域工作。 该仪器的升级功能允许活细胞分析，以研究蠕虫老化卵中蛋白质定位的动态变化以及黏菌中钙水平的响应。 改进的图像采集和渲染软件也将使人们更好地了解虾的肌肉和生殖细胞发育。 额外的激光线将加强几项研究，包括：酵母中发酵抑制剂反应的染色质结构，大鼠干细胞分化和神经适应，以及玉米早期发育的调节。 新的激光扫描共聚焦显微镜的收购也将积极影响和扩大我们的本科生和研究生的培训机会。谁追求的B.S.显微镜选项的学生。在生物学学位采取共聚焦显微镜必修课程，将特别受益于一个新的，国家的最先进的仪器。 计划毕业生应继续在全国首屈一指的研究机构就业的良好记录。 该奖项的积极影响和成果将包括提高研究生产力和加强学生培训，并将在部门网站和同行评审期刊上传播。

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).The Biology Department Microscopy Facility at Central Michigan University will acquire a Laser Scanning Confocal Microscope with this award from the Major Research Instrumentation program. The new instrument will have increased sensitivity, resolution, and scan speed to enable larger numbers and more diverse researchers across campus to conduct co-localization studies and enhanced 3-dimensional reconstructions of fluorescently-labeled samples. The users whose research will benefit from the new instrument include ten faculty and their students who work in the areas of developmental biology, cell biology, molecular genetics, neuroscience, and plant biology. The upgraded features of the instrument allow live-cell analyses required to study the dynamic changes in localization of proteins in both aging eggs in worms and in response to calcium levels in the slime mold. The improved image acquisition and rendering software will also allow for a better understanding of muscle and germ cell development in shrimp. Additional laser lines will enhance several studies including: chromatin structure in response to fermentation inhibitors in yeast, stem cell differentiation and neuroadaptation in rats, and regulation of early development in maize. Acquisition of the new laser scanning confocal microscope will also positively impact and expand the training opportunities of our undergraduate and graduate students. Students who pursue the Microscopy option of the B.S. degree in Biology take a required course in confocal microscopy and will particularly benefit from a new, state-of-the-art instrument. Program graduates should continue to have an excellent track record of job placements at premier research institutions across the country. Positive impacts and outcomes of this award will include increased research productivity and enhanced student training and will be disseminated on the departmental website and in peer reviewed journals.