MRI: Development of Spectroscopic Imaging Optical Bottles for Analysis of Nanoparticles in Confinement

MRI：开发用于分析限制中纳米颗粒的光谱成像光学瓶

• 批准号: 0923299
• 负责人: Hsin-Chiao Ou-Yang
• 金额: $ 42.75万
• 依托单位: Lehigh University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-10-01 至 2013-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0923299&HistoricalAwards=false
• 关键词: MRI; Development; Spectroscopic; Imaging; Optical

0923299Ou-YangLehigh U.Technical Summary: As we enter into a world of nanotechnology, it is fundamentally important that we have the ability to characterize the material properties of nanoscale particles in their native environments. However, the currently available instruments are still limited in their abilities to quantify the properties of nanoscale materials because it is difficult to control and manipulate these particles due to their small size, Brownian motion, and the interactions with surfaces and among themselves. This project aims to develop an instrument that can control and manipulate multiple nanoparticles while their physical behavior and material properties are characterized. This project builds on a novel optical bottle method with an instrumental design suitable for in situ multiple optical diagnostics. The optical bottle formed by a focused laser beam can manipulate multiple nanoparticles in the size range of 10 to 200 nm, and confine them in a volume of approximately 1 micron cube. Because the polarization of the electric field in the optical bottle can be controlled in all three directions it is possible to manipulate particle orientations in the bottle. The instrument will be built on a laser scanning confocal optical microscope where optical manipulation, single and two-photon fluorescence imaging, spectroscopic analysis such as Raman spectroscopy and photoluminescence will be integrated into a flexible optical workstation. The instrument will be constructed by, and used for, a multidisciplinary team from academia and industry. It will be used to address a range of scientific and technological issues, including nanoparticle sorting, separation and nanostructure assemblies of synthetic as well as biological nanoparticles. Through the involvement of undergraduate, graduate and postgraduate young researchers and a K-12 outreach program, this project will educate a new generation of US workforce that understands nanoscale sciences, appreciates the potential of nanotechnology to the society, and is keenly aware of the impacts of nanotechnologies to the human health and our natural environments.Layman Summary: As we enter into a world of nanotechnology, it is fundamentally important that we have the ability to characterize the material properties of nanoscale particles in their native environments. However, the currently available instruments are still limited in their abilities to quantify the properties of nanoscale materials because it is difficult to control and manipulate these particles due to their small size, constant motion, and the interactions with surfaces and among themselves. This project aims to develop an instrument that can control and manipulate multiple nanoparticles while their physical behavior and material properties are characterized. This project builds on a novel optical bottle method with an instrumental design suitable for in situ multiple optical diagnostics. The optical bottle formed by a focused laser beam can manipulate nanoparticles that are more than a thousand times smaller than the thickness of a hair, and confine them in a volume a hundred times smaller than the tip of a sawing needle. The instrument will be built on a state-of-art optical microscope so the optical manipulation, optical imaging and advanced spectroscopic analysis of the confined nano objects can be performed in situ. The instrument will be constructed by, and used for, a multidisciplinary team from academia and industry. It will be used to address a range of scientific and technological issues, including nanoparticle sorting, separation and nanostructure assemblies of synthetic as well as biological nanoparticles. Through the involvement of undergraduate, graduate and postgraduate young researchers and a K-12 outreach program, this project will educate a new generation of US workforce that understands nanoscale sciences, appreciates the potential of nanotechnology to the society, and is keenly aware of the impacts of nanotechnologies to the human health and our natural environments.

0923299 Ou-YangLehigh U.技术总结：当我们进入纳米技术的世界时，我们有能力在其原生环境中表征纳米颗粒的材料特性是非常重要的。然而，目前可用的仪器仍然是有限的，在他们的能力，以量化纳米材料的性能，因为它是难以控制和操纵这些颗粒，由于它们的小尺寸，布朗运动，与表面和它们之间的相互作用。该项目旨在开发一种可以控制和操纵多个纳米粒子的仪器，同时表征其物理行为和材料特性。该项目建立在一种新的光学瓶方法与仪器设计适合在现场多个光学诊断。由聚焦激光束形成的光学瓶可以操纵10至200 nm尺寸范围内的多个纳米颗粒，并将它们限制在约1微米立方体的体积内。由于光瓶中电场的偏振可以在所有三个方向上控制，因此可以操纵瓶中的粒子取向。该仪器将建立在激光扫描共聚焦光学显微镜上，光学操作，单光子和双光子荧光成像，光谱分析，如拉曼光谱和光致发光将被集成到一个灵活的光学工作站。该工具将由来自学术界和工业界的多学科小组构建并供其使用。它将用于解决一系列科学和技术问题，包括纳米粒子分选，分离和合成以及生物纳米粒子的纳米结构组装。通过本科生、研究生和研究生年轻研究人员的参与以及K-12外展计划，该项目将教育新一代美国劳动力，他们了解纳米科学，欣赏纳米技术对社会的潜力，并敏锐地意识到纳米技术对人类健康和自然环境的影响。随着我们进入纳米技术的世界，我们有能力在其原生环境中表征纳米颗粒的材料特性是至关重要的。然而，目前可用的仪器仍然是有限的，在他们的能力，以量化的纳米材料的性能，因为它是难以控制和操纵这些颗粒由于其小尺寸，不断运动，并与表面和它们之间的相互作用。该项目旨在开发一种可以控制和操纵多个纳米粒子的仪器，同时表征其物理行为和材料特性。该项目建立在一种新的光学瓶方法与仪器设计适合在现场多个光学诊断。由聚焦激光束形成的光学瓶可以操纵比头发厚度小一千倍以上的纳米颗粒，并将它们限制在比锯针尖端小一百倍的体积中。该仪器将建立在最先进的光学显微镜上，因此可以在原位对受限的纳米物体进行光学操作，光学成像和高级光谱分析。该工具将由来自学术界和工业界的多学科小组构建并供其使用。它将用于解决一系列科学和技术问题，包括纳米粒子分选，分离和合成以及生物纳米粒子的纳米结构组装。通过本科生，研究生和研究生年轻研究人员的参与和K-12外展计划，该项目将教育新一代美国劳动力，了解纳米科学，欣赏纳米技术对社会的潜力，并敏锐地意识到纳米技术对人类健康和自然环境的影响。