IDR: A Cancer Sensor-on-a-Chip Using Integrated Biomechanical and Bioimpedance Cell Signatures

IDR：使用集成生物力学和生物阻抗细胞特征的癌症芯片传感器

• 批准号: 0925945
• 负责人: Masoud Agah
• 金额: $ 45.28万
• 依托单位: Virginia Polytechnic Institute and State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-15 至 2013-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0925945&HistoricalAwards=false
• 关键词: IDR; Cancer; Sensor; Chip; Using

The proposed research is directed at the development of a sensor-on-a-chip to be fabricated using MEMS technology. The chip combined mechanical and electrical measurements of cells to potentially detect cells that are in a cancerous or pre-cancerous state. The detection sensitivity will be enhanced by utilizing three-dimensional microenvironments to sort cells on the basis of differences in adhesion and deformation properties. This is a highly interdisciplinary research endeavor, and the research team represents areas of expertise ranging from engineering to medical science.The significant aspects of education and outreach in the proposed effort include: development of presentation materials for the pre-college initiative and outreach program of the university; research opportunities for high school students and undergraduates; and recruitment of graduate students from under-represented groups.

所提出的研究是针对一个芯片上的传感器的发展，使用MEMS技术制造。 该芯片结合了细胞的机械和电气测量，以潜在地检测处于癌或癌前状态的细胞。 通过利用三维微环境来基于粘附和变形性质的差异分选细胞，将提高检测灵敏度。 这是一个高度跨学科的研究奋进，研究团队代表了从工程到医学的专业领域。在拟议的努力中，教育和推广的重要方面包括：为大学预科计划和大学推广计划开发演示材料;为高中生和本科生提供研究机会;以及从代表性不足的群体中招募研究生。