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Nutrient Uptake and Metabolic Adaptation by the Oomycete Plant Pathogen Phytophthora Infestans

卵菌植物病原体致病疫霉的养分吸收和代谢适应

基本信息

批准号：
0949426
负责人：
Howard Judelson
金额：
$ 50.4万
依托单位：
University of California-Riverside
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-01 至 2014-08-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=0949426&HistoricalAwards=false
关键词：
Nutrient Uptake Metabolic Adaptation Oomycete

项目摘要

Two indispensable attributes of all organisms are the abilities to absorb nutrients and adapt their metabolism to changes in the environment. The Judelson laboratory will study these processes in the microbe Phytophthora infestans, which causes the economically important late blight diseases of potato and tomato. P. infestans is believed to absorb nutrients during plant infection through the use of specialized structures that it inserts into host cells, and to adjust its metabolism to adapt to the nutrients encountered in its different hosts, but neither phenomenon is well-understood. A combination of molecular and cellular tools will be used to explore these processes, such as methods to identify genes that are turned on and off in response to different feeding conditions and techniques to localize within P. infestans the proteins that participate in nutrient sensing and uptake. This work is significant since organisms like P. infestans cause disease on hundreds of different plant species, and those diseases are difficult to control with existing tools. The research may lead to practical applications, such as inhibitors of the pathways used to assimilate nutrients which might be used to reduce the incidence of disease. The project also integrates research, education, and outreach at several levels as it will support junior scientists and graduate students, as well as undergraduates that might be interested in careers in science.

所有生物体的两个不可或缺的属性是吸收营养和使其新陈代谢适应环境变化的能力。 Judelson实验室将在致病疫霉（Phytophthora infestans）中研究这些过程，致病疫霉会导致马铃薯和番茄的经济上重要的晚疫病。致病疫霉被认为在植物感染期间通过使用插入宿主细胞的专门结构吸收营养，并调整其代谢以适应其不同宿主中遇到的营养，但这两种现象都没有得到很好的理解。分子和细胞工具的组合将用于探索这些过程，例如识别响应于不同饲养条件而打开和关闭的基因的方法，以及在P. infestans内定位参与营养感测和吸收的蛋白质的技术。这项工作意义重大，因为像P.infestans这样的生物会在数百种不同的植物物种上引起疾病，而这些疾病很难用现有的工具控制。这项研究可能会导致实际应用，例如用于吸收营养物质的途径的抑制剂，这可能会用于降低疾病的发病率。该项目还在多个层面上整合了研究，教育和推广，因为它将支持初级科学家和研究生，以及可能对科学职业感兴趣的本科生。