RUI: COLLABORATIVE RESEARCH. Non-uniform distribution of muscle fiber strain in squid mantle muscle: implications for musculoskeletal system structure, function, and evolution.

芮：合作研究。

• 批准号: 0951067
• 负责人: William Kier
• 金额: $ 27.2万
• 依托单位: University of North Carolina at Chapel Hill
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0951067&HistoricalAwards=false
• 关键词: RUI; COLLABORATIVE; RESEARCH.; Non; uniform

RUI: COLLABORATIVE RESEARCH. Non-uniform distribution of muscle fiber strain in squid mantle muscle: implications for musculoskeletal system structure, function, and evolution. Joseph T. Thompson (Franklin & Marshall College) and William M. Kier (University of North Carolina), Co-PIs.Proposal # IOS-0950827AbstractThe hollow, cylindrical shape of the bodies and muscular organs of soft-bodied invertebrate animals is well suited to functions in skeletal support, movement and locomotion. This ubiquitous shape, however, may incur a previously unrecognized cost - large non-uniformities in shortening among the muscle cells arranged circumferentially around the body. Such non-uniformities pose serious problems for the muscles, connective tissues, and neural control systems of the muscular organ, and may force muscle cells in some regions of the body wall to operate with reduced mechanical efficiency during locomotion and movement. We have identified a hollow cylindrical muscular organ, the mantle of squids, in which circumferential muscle cells at different locations likely produce different amounts of force, shorten at different velocities, and generate different amounts of mechanical work during a single contraction of the tubular body. We will use morphological, electromyographic, and biomechanical approaches to investigate these potential problems and identify mechanisms in the skeletal support system of the mantle that may mitigate them. The results of our work promise to reveal new general principles of function for skeletal support systems, not just for soft-bodied invertebrates but for all animals with cylindrical muscular organs. Our research will provide opportunities for undergraduate and graduate students from diverse ethnic backgrounds to learn experimental techniques in kinematics, muscle physiology, and microscopy. Furthermore, our student participants will gain experience in the collaborative and integrative nature of science as they work in teams with peers from different institutions to collect and analyze data, and present the results of their work at national and local scientific conferences.

RUI：合作研究。鱿鱼外套膜肌纤维应变的不均匀分布：对肌肉骨骼系统结构、功能和进化的影响。 约瑟夫·T汤普森（富兰克林马歇尔学院）和威廉M. Kier（北卡罗来纳州大学），联合PI，提案号IOS-0950827摘要软体无脊椎动物的身体和肌肉器官的中空、圆柱形形状非常适合于骨骼支撑、运动和移动的功能。 然而，这种普遍存在的形状可能会导致以前未被认识到的成本-在围绕身体周向排列的肌肉细胞之间的缩短中的巨大不均匀性。 这种不均匀性对肌肉器官的肌肉、结缔组织和神经控制系统造成严重的问题，并且可能迫使体壁的某些区域中的肌肉细胞在运动和移动期间以降低的机械效率操作。 我们已经确定了一个中空的圆柱形肌肉器官，鱿鱼的外套膜，其中不同位置的圆周肌细胞可能产生不同数量的力，以不同的速度缩短，并在管状体的单次收缩期间产生不同数量的机械功。 我们将使用形态学，肌电图和生物力学的方法来研究这些潜在的问题，并确定机制，在骨骼支持系统的地幔，可能会减轻他们。 我们的工作结果有望揭示骨骼支持系统功能的新的一般原则，不仅适用于软体无脊椎动物，而且适用于所有具有圆柱形肌肉器官的动物。 我们的研究将为来自不同种族背景的本科生和研究生提供学习运动学，肌肉生理学和显微镜实验技术的机会。 此外，我们的学生参与者将获得科学的协作和综合性质的经验，因为他们与来自不同机构的同行团队合作，收集和分析数据，并在国家和地方科学会议上展示他们的工作成果。