CAREER: Enabling the Synthesis of Nitrogen-Containing Complex Molecules

职业：实现含氮复杂分子的合成

• 批准号: 0955864
• 负责人: Neil Garg
• 金额: $ 55万
• 依托单位: University of California-Los Angeles
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0955864&HistoricalAwards=false
• 关键词: CAREER; Enabling; Synthesis; Nitrogen; Containing

With this CAREER award, the Chemical Synthesis program is supporting the research of Professor Neil K. Garg of the University of California, Los Angeles. Professor Garg will develop new methodologies for the synthesis of nitrogen-containing complex molecules. First, methods for synthesizing indolynes, or aryne derivatives of indoles, will be developed. These efforts will enable various studies of fundamental indolyne reactivity. Second, Professor Garg will uncover methods for preparing fused indolines, motifs often encountered in naturally occurring complex molecules. This latter methodology will be applied toward the total synthesis of aspidophylline A, an intriguing alkaloid that possesses a densely functionalized furoindoline core.Professor Garg will also undertake three educational projects that interweave research and teaching. The first project involves an outreach program targeting a local high school that predominantly serves underrepresented groups. The second educational project involves interactions with the NSF Research Experience for Undergraduates (REU) program, where Professor Garg will serve as an alumni advisor for the international NSF/REU program. Finally, an extensive synthetic organic chemistry website will be created that utilizes visual aids to convey the importance of chemical synthesis and explain various experimental techniques.

有了这个职业奖，化学合成计划是支持教授尼尔K。位于洛杉矶的加州大学的Garg说。 Garg教授将开发合成含氮复杂分子的新方法。首先，将开发合成吲哚炔或吲哚的芳炔衍生物的方法。 这些努力将使各种研究的基本吲哚反应性。第二，Garg教授将揭示制备融合吲哚啉的方法，这种基序经常在自然发生的复杂分子中遇到。后一种方法将应用于aspidophylline A的全合成，这是一种有趣的生物碱，具有密集功能化的furoindoline核心。Garg教授还将承担三个教育项目，将研究和教学交织在一起。 第一个项目涉及一个针对当地一所主要为代表性不足的群体服务的高中的外联方案。 第二个教育项目涉及与NSF本科生研究经验（REU）计划的互动，Garg教授将担任国际NSF/REU计划的校友顾问。 最后，将创建一个广泛的合成有机化学网站，利用视觉辅助工具来传达化学合成的重要性并解释各种实验技术。