CAREER: Evolving new synthetic chemistry in living organisms

职业：在生物体中发展新的合成化学

• 批准号: 0956161
• 负责人: Michelle Chang
• 金额: $ 68.5万
• 依托单位: University of California-Berkeley
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0956161&HistoricalAwards=false
• 关键词: CAREER; Evolving; new; synthetic; chemistry

This award in the Chemistry of Life Processes program of the Chemistry Division is co-funded by the Biomolecular Systems Cluster in the Division of Molecular and Cellular Biosciences. The award supports work by Professor Michelle Chang at the University of California, Berkeley to develop synthetic biology approaches to engineering microbes for new chemical function. The project focuses on designing and building pathways for the production of second-generation biofuels in Escherichia coli, with the overall goal of using engineered pathways to help understand the design principles that drive metabolic networks in vivo. Problems associated with heterologous pathway construction as well as how foreign synthetic pathways interact with the host metabolic machinery will be examined. The development and implementation of "Chemistry and Sustainability" educational modules seeks to build awareness of issues at the science/society interface in young students at the K-5 level and promote science education and literacy in local elementary schools. The overall goal of the integrated research and education program is focused on forming deeper connections between chemistry, sustainability, and society. The research component of the program is aimed at increasing the understanding of how chemistry works inside the cell while exploring the cell as a green alternative for sustainable synthetic chemistry. In education, this project seeks to attract youth to scientific disciplines and emphasize the importance of science to everyday life.

该化学划分的化学过程中的奖项是由分子和细胞生物科学划分的生物分子系统集群共同资助的。该奖项支持加利福尼亚大学伯克利分校的米歇尔·张教教授的工作，以开发合成生物学方法，用于工程微生物的新化学功能。该项目的重点是设计和建立途径，用于在大肠杆菌中生产第二代生物燃料，其总体目标是使用工程途径来帮助了解在体内推动代谢网络的设计原理。将检查与异源途径构建以及外国合成途径与宿主代谢机械相互作用的问题。 “化学和可持续性”教育模块的发展和实施旨在在K-5级别的年轻学生的科学/社会界面上建立对问题的认识，并促进当地小学的科学教育和素养。综合研究和教育计划的总体目标是建立化学，可持续性和社会之间更深层次的联系。该程序的研究组成部分旨在提高对化学在细胞内部如何工作的理解，同时探索细胞作为可持续合成化学的绿色替代方案。在教育方面，该项目旨在吸引青年进入科学学科，并强调科学对日常生活的重要性。