Functions of Stromal Chaperones in Chloroplasts of Physcomitrella Patens

立碗藓叶绿体基质伴侣的功能

• 批准号: 0956484
• 负责人: Steven Theg
• 金额: $ 66.55万
• 依托单位: University of California-Davis
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-15 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0956484&HistoricalAwards=false
• 关键词: Functions; Stromal; Chaperones; Chloroplasts; Physcomitrella

Intellectual Merit: Chloroplasts are the organelles within plant cells that are responsible for the synthesis of organic molecules from the energy contained in sunlight. This process of photosynthesis is the ultimate source of all food available on the planet. In order for chloroplasts to function they must be able to take up proteins needed for their biosynthesis and homeostasis from the cytoplasm, and this requires the input of metabolic energy. The molecular machinery responsible for the input of energy into the chloroplast protein import process is the subject of this research. Specifically, the synergistic interaction of two different molecular chaperones in powering chloroplast protein import will be examined, both in isolation and in the chloroplast itself. Elucidation of the details of this relationship is expected to inform future choices for modifications designed to improve the energy use efficiency of chloroplast biosynthesis and maintenance pathways. Broader impact: During the course of this research a number of young scientists will be trained in various disciplines of biological sciences. This will include a senior researcher, a graduate student and numerous undergraduates. These are the individuals who will be tasked with carrying forward biological research into the coming decades, including designing strategies for feeding the ever increasing world population. A number of the undergraduates will be drawn from the UC-Davis Biology Undergraduates Scholars Program, which serves students from economically depressed circumstances or underrepresented ethnic groups, thereby leading to greater diversity in our future scientific leaders.

智力优势：叶绿体是植物细胞内的细胞器，负责从阳光中吸收能量合成有机分子。光合作用的过程是地球上所有食物的最终来源。为了使叶绿体发挥作用，它们必须能够从细胞质中摄取其生物合成和稳态所需的蛋白质，这需要代谢能量的输入。负责将能量输入到叶绿体蛋白质输入过程的分子机制是本研究的主题。具体来说，两种不同的分子伴侣在为叶绿体蛋白进口提供动力方面的协同相互作用将被检查，无论是在单独的还是在叶绿体本身。阐明这一关系的细节有望为未来的修饰选择提供信息，以提高叶绿体生物合成和维持途径的能量利用效率。更广泛的影响：在这项研究的过程中，一些年轻的科学家将在生物科学的各个学科接受培训。这将包括一名高级研究员，一名研究生和许多本科生。这些人的任务是在未来几十年里推进生物学研究，包括设计养活不断增长的世界人口的策略。一些本科生将从加州大学戴维斯分校生物学本科生学者计划中选拔，该计划为来自经济不景气或代表性不足的种族的学生提供服务，从而使我们未来的科学领袖更加多样化。