Generation and Detection of Chemically Active Species with Nanometer Precision around Nanostructures in Aqueous Solution

美国国家科学基金会化学部的大分子、超分子和纳米化学（MSN）项目将支持美国加州大学戴维斯分校郭挺教授的研究项目。郭教授和他的学生将研究x射线辐射对纳米粒子表面化学的影响。要验证的假设是，用x射线照射纳米粒子会从表面释放出电子和自由基等化学反应物质，这些化学反应物质可以在纳米尺度上诱导局部化学反应。如果得到证实，这一独特的现象将在与纳米化学相关的多个传统学科中开辟新的研究途径。该项目将对辐射物理与化学、自由基化学、大分子化学、材料化学等领域产生重大影响。这项研究的结果也将为旨在开发x射线造影剂，放射治疗，先进的3D纳米材料网络和结构以及关于电离辐射与纳米材料相互作用的理论的一般研究提供指导。这项研究将为本科生和研究生提供良好的培训机会，他们将获得化学合成和表征、生物化学的重要技能，并对新兴的跨学科纳米化学领域有更全面的了解。

The Macromolecular, Supramolecular and Nanochemistry (MSN) program of the NSF Division of Chemistry will support the research project of Prof. Ting Guo of the University of California at Davis. Prof. Guo and his students will investigate the effect of X-ray radiation on the surface chemistry of nanoparticles. The hypothesis to be tested is that irradiation of nanoparticles with X-rays release chemically reactive species like electrons and free radicals from the surface and these chemically reactive species could induce localized chemistry at the nanometer scale. If confirmed, this unique phenomenon will open up new research avenues in multiple traditional disciplines associated with nanochemistry. The project will have a significant impact on the fields of radiation physics and chemistry, radical chemistry, macromolecular chemistry and materials chemistry. The results of this study will also provide guidance to general studies aiming to develop X-ray contrast agents, radiation therapy, advanced 3D nanomaterial networks and architectures, and theories regarding the interactions of ionizing radiation with nanomaterials. The study will provide excellent training opportunities to undergraduate and graduate students who will acquire important skills in chemical synthesis and characterization, and biochemistry and a more holistic understanding of the emerging interdisciplinary field of nanochemistry.