RUI: Activation of Small Molecules by Hexanuclear Clusters

RUI：六核团簇激活小分子

• 批准号: 0957729
• 负责人: Lisa Szczepura
• 金额: $ 30.75万
• 依托单位: Board of Trustees of Illinois State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0957729&HistoricalAwards=false
• 关键词: RUI; Activation; Small; Molecules; Hexanuclear

This award in the Chemical Synthesis (SYN) program supports work by Professor Lisa F. Szczepura at Illinois State University to carry out fundamental studies to determine the scope and mechanism of small molecule activation by octahedral hexanuclear metal complexes. The reactions of interest are [2+3] dipolar cycloadditions and nucleophilic additions involving nitriles, isonitriles, and azides. The reactivity of different terminal ligands will be investigated, and a study of the mechanistic aspects of these reactions will be performed. These investigations will result in a deeper understanding of the factors that influence small molecule activation by these cluster cores. In addition, these studies will help probe potential applications of octahedral cluster complexes as catalysts and as building blocks in new solid state materials. By incorporating successful concepts from the Enrichment Workshop Program, developed with funds from a CAREER award, into her mentoring and research efforts, the PI hopes to generate well trained, motivated, underrepresented scientists at the undergraduate and graduate levels. In particular, mentorship of freshman or sophomore students from groups that are underrepresented in the sciences will help increase the retention and success rate of these students at Illinois State University. These studies will provide a better understanding of the activation of small organic molecules by transition metal clusters and will lend insight into the mechanistic aspects of this activation. Small molecule activation involves the formation of a number of fundamentally important compounds that play key roles in organic synthesis, and in a number of different industries including: pharmaceuticals, explosives, dyes and agriculture.

该化学合成（SYN）计划的奖项支持伊利诺伊州立大学Lisa F. Szczepura教授进行的工作，以进行基本研究，以确定八面体六核金属复合物的小分子激活的范围和机制。 感兴趣的反应是[2+3]偶极环加成和涉及硝酸盐，异硝基和叠氮化物的亲核加成。 将研究不同末端配体的反应性，并将研究这些反应的机械方面。 这些研究将使人们更深入地了解影响这些簇核的小分子激活的因素。 此外，这些研究将有助于探测八面体簇复合物作为催化剂和新固态材料中的基础的潜在应用。 PI通过将凭借职业奖的资金开发的丰富研讨会计划的成功概念纳入她的指导和研究工作中，PI希望能在本科和研究生级别产生训练有素，积极进取，代表性不足的科学家。 尤其是，来自科学人数不足的小组的新生或大二学生的指导将有助于提高伊利诺伊州立大学这些学生的保留率和成功率。这些研究将通过过渡金属簇更好地了解小有机分子的激活，并将深入了解该激活的机械方面。 小分子激活涉及形成多种重要的化合物，这些化合物在有机合成中起着关键作用，在许多不同的行业中起着关键作用，包括：药品，炸药，染料，染料和农业。