MRI-R2: Acquisition of a Triple Quadrupole Mass Spectrometer

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。洛约拉大学的Michael P. Chiarelli和Nancy C. Tuchman以及东北伊利诺伊大学的Pamela Geddes将获得一台配备超高效液相色谱（UPLC）系统的三重四极质谱计（MS/MS）。该仪器将支持芝加哥洛约拉大学城市环境研究与政策中心（CUERP）的工作。该仪器将成为CUERP“清洁空气，清洁水”项目（CACW）的主要研究工具，在该项目中，在芝加哥地区及其周围的自然水生生态系统中发现的紧急污染物，以及这些化合物及其代谢物的命运，将在洛约拉大学的人工溪流设施中进行实验处理，以确定它们对水生生物群和功能的影响。其他研究项目包括：1)确定被认为是引发疟疾关键的蛋白质磷酸化位置的研究，以及2)确定由亲二烯试剂气相修饰rubrene晶体形成的有机半导体的结构。质谱仪是通过测量样品中分子组分电离后经质谱仪检测后的质量，来鉴定样品的化学成分。液相色谱法是一种在质谱仪电离化学物质之前将它们从混合物或溶液中分离出来的技术。该仪器将为洛约拉大学和东北伊利诺伊大学化学系和生物系的核心教职员用户提供混合物和反应产物化学成分的结构和定量表征。

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).Michael P. Chiarelli and Nancy C. Tuchman of Loyola University and Pamela Geddes of Northeastern Illinois University will acquire a triple quadrupole mass spectrometer (MS/MS) equipped with an ultra-performance liquid chromatography (UPLC) system. The instrument will support work at the Center for Urban Environmental Research & Policy (CUERP) at Loyola University Chicago. The instrument will be a primary tool for research within CUERP's "Clean Air, Clean Water" program (CACW), in which emergent contaminants found in natural aquatic ecosystems in and around the Chicago area as well as the fate of these compounds and their metabolites will be experimentally manipulated at Loyola's artificial stream facility to determine their effects on aquatic biota and functioning. Additional research projects include: 1) studies to determine the positions of phosphorylation in proteins suggested to be key in triggering malaria, and 2) determination of the structures of organic semiconductors formed by the gas-phase modification of rubrene crystals by dieneophiles.A mass spectrometer is used to identify the chemical composition of a sample by measuring the mass of the molecular constituents in the sample after they are ionized and detected by the mass spectrometer. Liquid chromatography is a technique that separates chemicals from a mixture or in a solution before they are ionized by the mass spectrometer. The instrument will provide structural and quantitative characterization of the chemical composition of mixtures and reaction products for a core group of faculty users from the Departments of Chemistry and Biology at Loyola University and Northeastern Illinois University.