MRI-R2: Acquisition of a Triple Quadrupole Mass Spectrometer

MRI-R2：购买三重四极杆质谱仪

• 批准号: 0960236
• 负责人: Michael Chiarelli
• 金额: $ 35.57万
• 依托单位: Loyola University of Chicago
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-02-01 至 2013-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0960236&HistoricalAwards=false
• 关键词: MRI; R2; Acquisition; Triple; Quadrupole

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).Michael P. Chiarelli and Nancy C. Tuchman of Loyola University and Pamela Geddes of Northeastern Illinois University will acquire a triple quadrupole mass spectrometer (MS/MS) equipped with an ultra-performance liquid chromatography (UPLC) system. The instrument will support work at the Center for Urban Environmental Research & Policy (CUERP) at Loyola University Chicago. The instrument will be a primary tool for research within CUERP's "Clean Air, Clean Water" program (CACW), in which emergent contaminants found in natural aquatic ecosystems in and around the Chicago area as well as the fate of these compounds and their metabolites will be experimentally manipulated at Loyola's artificial stream facility to determine their effects on aquatic biota and functioning. Additional research projects include: 1) studies to determine the positions of phosphorylation in proteins suggested to be key in triggering malaria, and 2) determination of the structures of organic semiconductors formed by the gas-phase modification of rubrene crystals by dieneophiles.A mass spectrometer is used to identify the chemical composition of a sample by measuring the mass of the molecular constituents in the sample after they are ionized and detected by the mass spectrometer. Liquid chromatography is a technique that separates chemicals from a mixture or in a solution before they are ionized by the mass spectrometer. The instrument will provide structural and quantitative characterization of the chemical composition of mixtures and reaction products for a core group of faculty users from the Departments of Chemistry and Biology at Loyola University and Northeastern Illinois University.

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助。Loyola大学的Tuchman和东北伊利诺伊大学的Pamela Geddes将获得一台配备超高效液相色谱（UPLC）系统的三重四极杆质谱仪（MS/MS）。 该仪器将支持芝加哥洛约拉大学城市环境研究政策中心的工作。 该仪器将是CUERP的“清洁空气，清洁水”计划（CACW），其中在自然水生生态系统中发现的紧急污染物和周围的芝加哥地区以及这些化合物及其代谢物的命运内的研究的主要工具将在洛约拉的人工流设施进行实验操作，以确定其对水生生物群和功能的影响。其他研究项目包括：1）确定蛋白质中磷酸化位置的研究表明是引发疟疾的关键，和2）确定由气体形成的有机半导体的结构-红荧烯晶体被亲双烯体的相改变。质谱仪用于通过测量样品中的分子成分在它们被电离后的质量来鉴定样品的化学组成并由质谱仪检测。 液相色谱法是一种在化学物质被质谱仪电离之前从混合物或溶液中分离化学物质的技术。 该仪器将为洛约拉大学和东北伊利诺伊大学化学和生物学系的核心教师用户提供混合物和反应产物的化学组成的结构和定量表征。