MRI-R2: Acquisition of a Triple Quadrupole Mass Spectrometer

该奖项是根据2009年《美国复苏和再投资法案》(Public Law 111-5)获得的。洛约拉大学的Michael P.Chiarelli和Nancy C.Tuchman以及东北伊利诺伊大学的Pamela Geddes将获得一台配备超高效液相色谱(UPLC)系统的三重四极杆质谱仪(MS/MS)。该仪器将支持芝加哥洛约拉大学城市环境研究与政策中心(CUERP)的工作。该仪器将是CUERP“清洁空气，清洁水”计划(CACW)研究的主要工具，在该计划中，芝加哥地区及其周围的自然水生生态系统中发现的紧急污染物以及这些化合物及其代谢物的命运将在Loyola的人工河流设施中进行实验操作，以确定它们对水生生物群和功能的影响。其他研究项目包括：1)确定蛋白质中被认为是引发疟疾的关键的磷酸化位置的研究，以及2)通过双亲分子对Rubrene晶体进行气相修饰而形成的有机半导体的结构的确定。质谱仪用于通过测量样品中的分子组成的质量来确定样品的化学成分，样品被电离后由质谱仪检测。液相色谱是一种在化学物质被质谱仪电离之前将其从混合物或溶液中分离出来的技术。该仪器将为来自洛约拉大学和东北伊利诺伊大学化学和生物系的核心教职员工用户提供混合物和反应产物的结构和定量表征。

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).Michael P. Chiarelli and Nancy C. Tuchman of Loyola University and Pamela Geddes of Northeastern Illinois University will acquire a triple quadrupole mass spectrometer (MS/MS) equipped with an ultra-performance liquid chromatography (UPLC) system. The instrument will support work at the Center for Urban Environmental Research & Policy (CUERP) at Loyola University Chicago. The instrument will be a primary tool for research within CUERP's "Clean Air, Clean Water" program (CACW), in which emergent contaminants found in natural aquatic ecosystems in and around the Chicago area as well as the fate of these compounds and their metabolites will be experimentally manipulated at Loyola's artificial stream facility to determine their effects on aquatic biota and functioning. Additional research projects include: 1) studies to determine the positions of phosphorylation in proteins suggested to be key in triggering malaria, and 2) determination of the structures of organic semiconductors formed by the gas-phase modification of rubrene crystals by dieneophiles.A mass spectrometer is used to identify the chemical composition of a sample by measuring the mass of the molecular constituents in the sample after they are ionized and detected by the mass spectrometer. Liquid chromatography is a technique that separates chemicals from a mixture or in a solution before they are ionized by the mass spectrometer. The instrument will provide structural and quantitative characterization of the chemical composition of mixtures and reaction products for a core group of faculty users from the Departments of Chemistry and Biology at Loyola University and Northeastern Illinois University.