Collaborative Research: Large-Scale Nanomanufacturing of Well-Positioned and Highly Aligned DNA Wires from a Capillary Bridge

合作研究：从毛细管桥大规模纳米制造定位良好且高度对齐的 DNA 线

• 批准号: 0968656
• 负责人: Zhiqun Lin
• 金额: --
• 依托单位: Iowa State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0968656&HistoricalAwards=false
• 关键词: Collaborative; Research; Large; Scale; Nanomanufacturing

The research objective of this project is to develop simple yet robust methods for massively producing well-positioned nanostructured materials composed of DNA or DNA-based nanocomposites, which possess unprecedented regularity, over a large area (i.e., large scale). Subsequent functionalization of highly ordered DNA can serve as multifunctional materials for a variety of potential applications in nanoelectronic devices. Three specific research goals will be pursued throughout this proposed project: (1) Produce highly ordered structures of DNA and DNA-based nanocomposites by controlling the flow of an evaporating liquid. (2) Develop a reliable and scalable strategy for integrating individual nanoscale building blocks (i.e., DNA) into functional two-dimensional devices with high density. By performing two consecutive evaporation-induced self-assemblies, it is possible to create highly ordered 2D DNA nanowire arrays. (3) Understand the formation mechanisms of ordered structures. The ability to predict the length scale of periodicity, height, and width and compare them with experimental observations is key to the understanding on the structure formation. This research is transformative in that it seeks to mass produce high-density functional nanodevices and nanocircuits, built upon well-positioned, highly ordered DNA or DNA nanocomposites for use in nanoelectronics, nanotechnology, and biotechnology, thereby transitioning fundamental scientific discoveries into useful technologies. The research project will be integrated with nanoscience and nanoengineering education. The educational efforts include recruitment of female undergraduate students, recruitment of high school teachers and students with an emphasis on minority in summer to perform one week of research, and development of lesson plans on DNA and DNA-based nanocomposites by high-school female interns.

该项目的研究目标是开发简单而强大的方法，用于大规模生产由DNA或基于DNA的纳米复合材料组成的位置良好的纳米结构材料，这些材料具有前所未有的规律性，在大面积上（即，大规模）。高度有序的DNA的后续功能化可以作为多功能材料在纳米电子器件中的各种潜在应用。本计画主要有三个研究目标：（1）借由控制蒸发液体的流动，制造高度有序的DNA结构及以DNA为基础的奈米复合物。(2)开发一种可靠的、可扩展的策略，用于集成单个纳米级构建块（即，DNA）以高密度组装到功能性二维器件中。通过进行两次连续的蒸发诱导自组装，可以产生高度有序的2D DNA纳米线阵列。(3)理解有序结构的形成机制。预测周期性、高度和宽度的长度尺度并将其与实验观测进行比较的能力是理解结构形成的关键。这项研究是变革性的，因为它寻求大规模生产高密度功能纳米器件和纳米电路，建立在定位良好，高度有序的DNA或DNA纳米复合材料上，用于纳米电子学，纳米技术和生物技术，从而将基础科学发现转化为有用的技术。该研究项目将与纳米科学和纳米工程教育相结合。教育工作包括招聘女大学生，招聘高中教师和学生（重点是少数民族）在夏季进行为期一周的研究，并由高中女实习生制定关于DNA和基于DNA的纳米复合材料的课程计划。