Collaborative Research: Large-Scale Nanomanufacturing of Well-Positioned and Highly Aligned DNA Wires from a Capillary Bridge

合作研究：从毛细管桥大规模纳米制造定位良好且高度对齐的 DNA 线

• 批准号: 0968846
• 负责人: Lei Zhu
• 金额: $ 10万
• 依托单位: Case Western Reserve University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0968846&HistoricalAwards=false
• 关键词: Collaborative; Research; Large; Scale; Nanomanufacturing

The research objective of this project is to develop simple yet robust methods for massively producing well-positioned nanostructured materials composed of DNA or DNA-based nanocomposites, which possess unprecedented regularity, over a large area (i.e., large scale). Subsequent functionalization of highly ordered DNA can serve as multifunctional materials for a variety of potential applications in nanoelectronic devices. Three specific research goals will be pursued throughout this proposed project: (1) Produce highly ordered structures of DNA and DNA-based nanocomposites by controlling the flow of an evaporating liquid. (2) Develop a reliable and scalable strategy for integrating individual nanoscale building blocks (i.e., DNA) into functional two-dimensional devices with high density. By performing two consecutive evaporation-induced self-assemblies, it is possible to create highly ordered 2D DNA nanowire arrays. (3) Understand the formation mechanisms of ordered structures. The ability to predict the length scale of periodicity, height, and width and compare them with experimental observations is key to the understanding on the structure formation. This research is transformative in that it seeks to mass produce high-density functional nanodevices and nanocircuits, built upon well-positioned, highly ordered DNA or DNA nanocomposites for use in nanoelectronics, nanotechnology, and biotechnology, thereby transitioning fundamental scientific discoveries into useful technologies. The research project will be integrated with nanoscience and nanoengineering education. The educational efforts include recruitment of female undergraduate students, recruitment of high school teachers and students with an emphasis on minority in summer to perform one week of research, and development of lesson plans on DNA and DNA-based nanocomposites by high-school female interns.

该项目的研究目标是开发简单而健壮的方法来大规模生产由DNA或DNA基纳米复合材料组成的位置良好的纳米结构材料，这些材料具有前所未有的规律性，可以在大范围(即大范围)上生产。随后的高度有序的DNA功能化可以作为多功能材料在纳米电子器件中的各种潜在应用。在整个拟议的项目中，将追求三个具体的研究目标：(1)通过控制蒸发液体的流动来制备高度有序的DNA和DNA基纳米复合材料。(2)开发可靠和可扩展的策略，将单个纳米级构建块(即DNA)集成到高密度的功能二维设备中。通过执行两个连续的蒸发诱导自组装，可以创建高度有序的2D DNA纳米线阵列。(3)了解有序结构的形成机制。预测周期、高度和宽度的长度尺度并将其与实验观测进行比较的能力是理解结构形成的关键。这项研究具有变革性，因为它寻求大规模生产高密度功能纳米设备和纳米电路，建立在位置良好、高度有序的DNA或DNA纳米复合材料的基础上，用于纳米电子学、纳米技术和生物技术，从而将基础科学发现转化为有用的技术。该研究项目将与纳米科学和纳米工程教育相结合。教育努力包括招募女本科生，招募高中教师和学生在夏季进行为期一周的研究，并由高中女实习生制定关于DNA和DNA基纳米复合材料的教案。