REU Site: Summer Research in Chemistry at Boise State University for First Year Undergraduates

这项由化学部(CHE)和生物基础设施部(DBI)颁发的奖项支持博伊西州立大学唐·L·华纳(Don L.Warner)领导的2010-2012年夏季本科生研究体验(REU)网站。该网站将在为期十周的计划中，每年夏天为十名学生提供支持。研究项目的重点是跨越化学和生物领域的研究。样本项目包括：(1)配位金属如何改变肽脱甲酰基酶的功能的研究；(2)合成的氮杂环丁二烯的DNA结合特性的研究；(3)人羰基还原酶对底物和抑制剂识别的研究；(4)耐甲氧西林金黄色葡萄球菌突变株群体感应的研究；(5)寡核苷酸功能化的胶体金纳米颗粒对DNA的比色检测；(6)椰螺毒素配体的结构和与金黄色葡萄球菌乙酰胆碱结合蛋白的结合的计算；(7)二硫代膦酸类配体与吖系元素结合的研究。除了接触引人注目的研究，参加这个项目的学生还将参加实地考察、社会活动和专业发展活动--包括关于同行指导(针对归国学生)和科学研究中的道德问题的会议。该网站将从研究基础设施较少的地区两年制和四年制大学招收一年级学生。许多目标学生是第一代大学生和在科学中代表性较低的其他群体的成员。年轻科学家需要接触现代研究方法和工具，作为他们培训的一部分。这个REU网站旨在为相当数量的学生提供实际的、动手的研究培训，这些学生在他们的母校可能没有这个机会。学生们在博伊西州立大学期间将从事的跨学科项目，是跨学科工作种类的极好例子，这种工作正变得越来越典型，成为现代实验室研究最富有成效的途径。在这个网站参与研究的学生将为进入研究生院做好准备，并最终成为国家技术劳动力的一部分。

This award from the Division of Chemistry (CHE) and the Division of Biological Infrastructure (DBI) supports a Research Experience for Undergraduates (REU) site led by Don L. Warner at Boise State University for the summers of 2010-2012. The site will support ten students per summer in a ten week program. The research projects focus on research in areas that span areas of chemistry and biology. Sample projects include: (1) a study of the ways in which the coordinating metal alters the functionality of the peptide deformylase enzyme; (2) the study of the DNA-binding properties of synthetic aziridinomitosenes; (3) the study of the substrate and inhibitor recognition by human carbonyl reductase; (4) the study of quorum sensing in mutants of methicillin resistant staphylococcus aureus; (5) the colorimetric detection of DNA with oligonucleotide-functionalized colloidal gold nanoparticles; (6) the calculation of the structure and binding of conotoxin ligands with the acetylcholine-binding protein of A. californica; and (7) the study of the binding of actinides with dithiophosphonic acid ligands. Besides being exposed to compelling research, the students participating in this program will participate in site visits, social activities, and professional development activities -- including sessions on peer mentoring (for returning students) and ethics in scientific research. The site will recruit from first year students from regional 2-year and 4-year colleges with little research infrastructure. Many of the targeted students are first-generation college students and members of other groups underrepresented in the sciences.Young scientists need exposure to modern research methods and tools as part of their training. This REU site aims to provide practical, hands-on research training to a significant number of students who might not have this opportunity at their home institution. The interdisciplinary projects that the students will work on while at Boise State University, are excellent examples of the kinds of cross-disciplinary work that is becoming more and more typical of the most fruitful avenues for modern laboratory research. Students participating in research at this site will be well-prepared for graduate school, and eventual employment as part of the country's technical workforce.