MRI: Acquisition of a 600 MHz NMR Console and Cryoprobe to Support Research and Education at Boise State University

博伊西州立大学获得了一份合同，将现有的600 MHz核磁共振（NMR）光谱仪现代化，配备新的冷冻探针、控制台和温控自动进样器。该光谱仪是爱达荷州最强大、最灵敏的光谱仪，将被安置在爱达荷州最大的公立大学博伊西州立大学的共享用户设施中，博伊西州立大学位于爱达荷州最大的大都市区。除了博伊西州立大学的研究人员外，光谱仪还将被用作研究项目的一部分，涉及邻近的文科和社区学院、当地工业和政府机构的用户。该设施将继续为来自不同背景的未来科学家提供现代核磁共振技术的培训，因为参与研究项目的研究生，本科生和高中生将由诸如NSF本科生研究经验，NSF路易斯斯托克斯少数民族参与联盟，TRiO，麦克奈尔学者，美国化学学会项目SEED，国立卫生研究院桥梁到学士学位，博伊西VA医疗中心等项目资助。核磁共振波谱是化学家、生物学家和工程师研究许多社会最大问题的关键工具，在这些问题中，分子结构或溶液动力学知识是必不可少的。因此，核磁共振波谱已被用于确认新制备的化合物和材料的身份，确定蛋白质的溶液结构，测量两个分子（例如，蛋白质和潜在药物）之间的相互作用，以及评估化学或生物反应的速率。博伊西州立大学装备有低温探针的600 MHz核磁共振光谱仪的现代化将有助于解决诸如了解抗生素耐药性的基本机制，寻求回收和再利用塑料的更好方法，同时开发传统塑料的可持续替代品，为量子计算开发新的基于dna的材料，研究涉及重要疾病的潜在生物机制等问题。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

An award is made to Boise State University to modernize an existing 600 MHz Nuclear Magnetic Resonance (NMR) spectrometer with a new cryoprobe, console, and temperature-controlled autosampler. The spectrometer, the most powerful and sensitive in the state of Idaho, will be housed in a shared user facility at Boise State University, Idaho’s largest public university, located in Idaho’s largest metropolitan area. In addition to those at Boise State University, the spectrometer will be used as part of research projects involving users from neighboring liberal arts and community colleges, local industry, and government agencies. The facility will continue to provide training in modern NMR techniques to future scientists from diverse backgrounds as the graduate, undergraduate, and high school students involved in the research projects will be funded by programs such as the NSF Research Experiences for Undergraduates, NSF Louis Stokes Alliances for Minority Participation, TRiO, McNair Scholars, American Chemical Society Project SEED, NIH Bridges-to-Baccalaureate, Boise VA Medical Center, among others. NMR spectroscopy is a critical tool for chemists, biologists, and engineers studying many of society’s biggest problems where knowledge of a molecule’s structure or dynamics in solution is essential. As such, NMR spectroscopy has been used for confirming the identity of newly prepared compounds and materials, determining the solution structure of proteins, measuring the interactions between two molecules (e.g., a protein and a potential drug), and evaluating the rates of chemical or biological reactions. The research projects enabled by the modernization of Boise State’s cryoprobe-equipped 600 MHz NMR spectrometer will help address problems such as understanding the fundamental mechanisms of antibiotic drug resistance, seeking better ways to recycle and reuse plastic while simultaneously developing sustainable alternatives to traditional plastics, developing new DNA-based materials for quantum computing, studying the underlying biological mechanism involved in important diseases.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.