MRI: Acquisition of a 600 MHz NMR Console and Cryoprobe to Support Research and Education at Boise State University

博伊西州立大学被授予对现有的600 MHz核磁共振(核磁共振)光谱仪进行现代化改造，以使用新的低温探头、控制台和温控自动取样器。这台光谱仪是爱达荷州最强大、最灵敏的光谱仪，将安装在爱达荷州最大的公立大学博伊西州立大学的一个共享用户设施中，博伊西州立大学位于爱达荷州最大的大都市区。除了博伊西州立大学的光谱仪外，该光谱仪还将被用作研究项目的一部分，研究项目涉及来自邻近文科和社区大学、当地工业和政府机构的用户。该设施将继续为来自不同背景的未来科学家提供现代核磁共振技术培训，因为参与研究项目的研究生、本科生和高中生将得到NSF本科生研究体验、NSF Louis Stokes少数民族参与联盟、TRIO、McNair学者、美国化学学会项目种子、NIH桥梁到文凭、博伊西退伍军人医学中心等项目的资助。核磁共振波谱是化学家、生物学家和工程师研究许多社会最大问题的关键工具，在这些问题中，了解分子结构或溶液中的动力学是必不可少的。因此，核磁共振波谱已被用于确认新制备的化合物和材料的特性，确定蛋白质的溶液结构，测量两个分子(例如，蛋白质和潜在药物)之间的相互作用，并评估化学反应或生物反应的速度。博伊西州立大学配备低温探头的600 MHz核磁共振波谱仪的现代化将有助于解决以下问题：了解抗生素耐药性的基本机制，寻求更好的回收和重复使用塑料的方法，同时开发传统塑料的可持续替代品，开发用于量子计算的基于DNA的新材料，研究重要疾病涉及的潜在生物学机制。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

An award is made to Boise State University to modernize an existing 600 MHz Nuclear Magnetic Resonance (NMR) spectrometer with a new cryoprobe, console, and temperature-controlled autosampler. The spectrometer, the most powerful and sensitive in the state of Idaho, will be housed in a shared user facility at Boise State University, Idaho’s largest public university, located in Idaho’s largest metropolitan area. In addition to those at Boise State University, the spectrometer will be used as part of research projects involving users from neighboring liberal arts and community colleges, local industry, and government agencies. The facility will continue to provide training in modern NMR techniques to future scientists from diverse backgrounds as the graduate, undergraduate, and high school students involved in the research projects will be funded by programs such as the NSF Research Experiences for Undergraduates, NSF Louis Stokes Alliances for Minority Participation, TRiO, McNair Scholars, American Chemical Society Project SEED, NIH Bridges-to-Baccalaureate, Boise VA Medical Center, among others. NMR spectroscopy is a critical tool for chemists, biologists, and engineers studying many of society’s biggest problems where knowledge of a molecule’s structure or dynamics in solution is essential. As such, NMR spectroscopy has been used for confirming the identity of newly prepared compounds and materials, determining the solution structure of proteins, measuring the interactions between two molecules (e.g., a protein and a potential drug), and evaluating the rates of chemical or biological reactions. The research projects enabled by the modernization of Boise State’s cryoprobe-equipped 600 MHz NMR spectrometer will help address problems such as understanding the fundamental mechanisms of antibiotic drug resistance, seeking better ways to recycle and reuse plastic while simultaneously developing sustainable alternatives to traditional plastics, developing new DNA-based materials for quantum computing, studying the underlying biological mechanism involved in important diseases.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.