Indolines as Precursors to Highly Congested Stereocenters

在这项由美国国家科学基金会化学部化学合成计划资助的项目中，犹他大学化学系的Jon D.Rainier教授将探索合成方法学的发展，目标是产生季系中心，重点是季系取代吲哚。这些努力将针对应变底物的产生及其在合成精细有机底物中的应用，并可能导致更有效和更通用的方法来合成高度拥挤的立体中心。这些努力可能会对制药、生物技术、化工和环境行业等各种行业产生影响。这项工作除了对合成化学产生影响外，还将对化学合成学本科生和研究生的培养和教育起到广泛而重要的作用。这群科学家将帮助确保美国继续在新技术的开发和应用方面保持领先地位。

In this project, funded by the Chemical Synthesis Program of the Chemistry Division of the National Science Foundation, Professor Jon D. Rainier of the Department of Chemistry at the University of Utah will explore the development of synthetic methodology aimed at the generation of quaternary centers with a focus on quaternary substituted indolines. These efforts will target the generation of strained substrates and their use in the synthesis of elaborate organic substrates and could lead to more efficient and more general methods to synthesize highly congested stereocenters. These efforts could have an impact in industries as diverse as the pharmaceutical, biotech, chemical, and environmental industries. In addition to its impact on synthetic chemistry, this work will play a broad and important role in the training and education of undergraduate and graduate students in the science of chemical synthesis. This group of scientists will help to ensure that the United States continues to remain a leader in the development and application of new technologies.