Indolines as Precursors to Highly Congested Stereocenters

本项目由美国国家科学基金会化学部化学合成计划资助，由美国国家科学基金会化学部化学合成计划主任乔恩·D·卡耐基教授主持。犹他州大学化学系的Rainier将探索旨在生成季中心的合成方法的发展，重点是季取代的吲哚啉。这些努力将针对应变基板的生成及其在合成精细有机基板中的用途，并可能导致更有效和更通用的方法来合成高度拥挤的立体中心。这些努力可能会对制药、生物技术、化学和环境行业等不同行业产生影响。 除了对合成化学的影响外，这项工作还将在化学合成科学的本科生和研究生的培训和教育中发挥广泛而重要的作用。这批科学家将有助于确保美国继续在新技术的开发和应用方面保持领先地位。

In this project, funded by the Chemical Synthesis Program of the Chemistry Division of the National Science Foundation, Professor Jon D. Rainier of the Department of Chemistry at the University of Utah will explore the development of synthetic methodology aimed at the generation of quaternary centers with a focus on quaternary substituted indolines. These efforts will target the generation of strained substrates and their use in the synthesis of elaborate organic substrates and could lead to more efficient and more general methods to synthesize highly congested stereocenters. These efforts could have an impact in industries as diverse as the pharmaceutical, biotech, chemical, and environmental industries. In addition to its impact on synthetic chemistry, this work will play a broad and important role in the training and education of undergraduate and graduate students in the science of chemical synthesis. This group of scientists will help to ensure that the United States continues to remain a leader in the development and application of new technologies.