Scaffolds for bone tissue regeneration and use in orthopaedic applications

骨组织再生支架及其在骨科应用中的应用

• 批准号: LP0991099
• 负责人: Prof Hala Zreiqat
• 金额: $ 35.35万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-09-18 至 2015-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP0991099
• 关键词: Scaffolds; bone; tissue; regeneration; use

Damaged joints do not repair spontaneously, often leading to arthritis. Bone defects resulting from congenital defects or disease processes are challenging to regenerate and represent a major financial burden to our health system. Bone graft treatments are widely used but have considerable drawbacks. This created a need for scaffolds to provide temporary support for new bone. However they lack the combined physical/biological properties necessary for bone repair. We developed new scaffolds with improved mechanical/biological properties to mimic bone which will lead to new treatments for bone damage.

受损的关节不会自发修复，通常会导致关节炎。由于先天缺陷或疾病过程导致的骨缺陷很难再生，并且是我们卫生系统的主要经济负担。骨移植治疗被广泛使用，但也有相当大的缺点。这就产生了对支架的需求，以提供新骨的临时支撑。然而，它们缺乏骨修复所需的综合物理/生物特性。我们开发了具有更好的力学/生物性能的新型支架来模拟骨，这将导致骨损伤的新治疗。